Details
Original language | English |
---|---|
Pages (from-to) | 3271-3274 |
Number of pages | 4 |
Journal | Angewandte Chemie |
Volume | 50 |
Issue number | 14 |
Publication status | Published - 28 Mar 2011 |
Externally published | Yes |
Abstract
New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.
Keywords
- antibiotics, biosynthesis, methicillin resistance, mupirocin, thiomarinol
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
Sustainable Development Goals
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In: Angewandte Chemie , Vol. 50, No. 14, 28.03.2011, p. 3271-3274.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390
AU - Murphy, Annabel C.
AU - Fukuda, Daisuke
AU - Song, Zhongshu
AU - Hothersall, Joanne
AU - Cox, Russell J.
AU - Willis, Christine L.
AU - Thomas, Christopher M.
AU - Simpson, Thomas J.
PY - 2011/3/28
Y1 - 2011/3/28
N2 - New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.
AB - New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.
KW - antibiotics
KW - biosynthesis
KW - methicillin resistance
KW - mupirocin
KW - thiomarinol
UR - http://www.scopus.com/inward/record.url?scp=79952999917&partnerID=8YFLogxK
U2 - 10.1002/anie.201007029
DO - 10.1002/anie.201007029
M3 - Article
C2 - 21381163
AN - SCOPUS:79952999917
VL - 50
SP - 3271
EP - 3274
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 14
ER -