Details
| Original language | English |
|---|---|
| Pages (from-to) | 61–78 |
| Number of pages | 18 |
| Journal | Nature Reviews Chemistry |
| Volume | 8 |
| Issue number | 1 |
| Early online date | 3 Jan 2024 |
| Publication status | Published - Jan 2024 |
Abstract
Filamentous fungi produce a very wide range of complex and often bioactive metabolites, demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent advances in molecular sciences related to fungi have afforded the development of new tools that allow the rational total biosynthesis of highly complex specialized metabolites in a single process. Increasingly, these pathways can also be engineered to produce new metabolites. Engineering can be at the level of gene deletion, gene addition, formation of mixed pathways, engineering of scaffold synthases and engineering of tailoring enzymes. Combination of these approaches with hosts that can metabolize low-value waste streams opens the prospect of one-step syntheses from garbage. [Figure not available: see fulltext.].
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Chemical Engineering(all)
- General Chemical Engineering
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In: Nature Reviews Chemistry, Vol. 8, No. 1, 01.2024, p. 61–78.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Engineered and total biosynthesis of fungal specialized metabolites
AU - Cox, Russell J.
PY - 2024/1
Y1 - 2024/1
N2 - Filamentous fungi produce a very wide range of complex and often bioactive metabolites, demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent advances in molecular sciences related to fungi have afforded the development of new tools that allow the rational total biosynthesis of highly complex specialized metabolites in a single process. Increasingly, these pathways can also be engineered to produce new metabolites. Engineering can be at the level of gene deletion, gene addition, formation of mixed pathways, engineering of scaffold synthases and engineering of tailoring enzymes. Combination of these approaches with hosts that can metabolize low-value waste streams opens the prospect of one-step syntheses from garbage. [Figure not available: see fulltext.].
AB - Filamentous fungi produce a very wide range of complex and often bioactive metabolites, demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent advances in molecular sciences related to fungi have afforded the development of new tools that allow the rational total biosynthesis of highly complex specialized metabolites in a single process. Increasingly, these pathways can also be engineered to produce new metabolites. Engineering can be at the level of gene deletion, gene addition, formation of mixed pathways, engineering of scaffold synthases and engineering of tailoring enzymes. Combination of these approaches with hosts that can metabolize low-value waste streams opens the prospect of one-step syntheses from garbage. [Figure not available: see fulltext.].
UR - http://www.scopus.com/inward/record.url?scp=85181255806&partnerID=8YFLogxK
U2 - 10.1038/s41570-023-00564-0
DO - 10.1038/s41570-023-00564-0
M3 - Review article
AN - SCOPUS:85181255806
VL - 8
SP - 61
EP - 78
JO - Nature Reviews Chemistry
JF - Nature Reviews Chemistry
IS - 1
ER -