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Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Paul Könst
  • Hedda Merkens
  • Selin Kara
  • Svenja Kochius

External Research Organisations

  • Delft University of Technology
  • c-LEcta GmbH
  • DECHEMA Research Institute (DFI)
  • Chiracon GmbH
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  • Citations
    • Citation Indexes: 72
  • Captures
    • Readers: 98
  • Mentions
    • References: 1
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Details

Original languageEnglish
Pages (from-to)9914-9917
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number39
Early online date31 Aug 2012
Publication statusPublished - 24 Sept 2012
Externally publishedYes

Abstract

Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.

Keywords

    alcohol dehydrogenases, alcohol oxidation, aldehyde oxidation, dynamic kinetic resolution, profens

ASJC Scopus subject areas

Cite this

Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase. / Könst, Paul; Merkens, Hedda; Kara, Selin et al.
In: Angewandte Chemie - International Edition, Vol. 51, No. 39, 24.09.2012, p. 9914-9917.

Research output: Contribution to journalArticleResearchpeer review

Könst, P, Merkens, H, Kara, S, Kochius, S, Vogel, A, Zuhse, R, Holtmann, D, Arends, IWCE & Hollmann, F 2012, 'Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase', Angewandte Chemie - International Edition, vol. 51, no. 39, pp. 9914-9917. https://doi.org/10.1002/anie.201203219, https://doi.org/10.1002/anie.201208486
Könst, P., Merkens, H., Kara, S., Kochius, S., Vogel, A., Zuhse, R., Holtmann, D., Arends, I. W. C. E., & Hollmann, F. (2012). Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase. Angewandte Chemie - International Edition, 51(39), 9914-9917. https://doi.org/10.1002/anie.201203219, https://doi.org/10.1002/anie.201208486
Könst P, Merkens H, Kara S, Kochius S, Vogel A, Zuhse R et al. Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase. Angewandte Chemie - International Edition. 2012 Sept 24;51(39):9914-9917. Epub 2012 Aug 31. doi: 10.1002/anie.201203219, 10.1002/anie.201208486
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AU - Kara, Selin

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AU - Vogel, Andreas

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AU - Holtmann, Dirk

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