Details
| Original language | English |
|---|---|
| Pages (from-to) | 209-220 |
| Number of pages | 12 |
| Journal | Advanced drug delivery reviews |
| Volume | 63 |
| Issue number | 4-5 |
| Early online date | 9 Dec 2010 |
| Publication status | Published - 30 Apr 2011 |
Abstract
Electrospinning is a versatile technique in tissue engineering for the production of scaffolds. To guide tissue development, scaffolds must provide specific biochemical, structural and mechanical cues to cells and deliver them in a controlled fashion over time. Electrospun scaffold design thus includes aspects of both controlled release and structural cues. Controlled multicomponent and multiphasic drug delivery can be achieved by the careful application and combination of novel electrospinning techniques, i.e., emulsion and co-axial electrospinning. Drug distribution and polymer properties influence the resulting release kinetics. Pore size is far more relevant as a structural parameter than previously recognized. It enables cell proliferation and ingrowth, whereas fiber diameter predominantly influences cell fate. Both parameters can be exploited by combining multiple fiber types in the form of multifiber and multilayer scaffolds. Such scaffolds are required to reproduce more complex tissue structures.
Keywords
- Cell ingrowth, Cell proliferation, Electrospinning, Fiber diameter, Pore size, Porosity, Protein delivery, Release kinetics, Tissue engineering
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
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In: Advanced drug delivery reviews, Vol. 63, No. 4-5, 30.04.2011, p. 209-220.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Electrospun cellular microenvironments
T2 - Understanding controlled release and scaffold structure
AU - Szentivanyi, Andreas
AU - Chakradeo, Tanmay
AU - Zernetsch, Holger
AU - Glasmacher, Birgit
N1 - Funding Information: This work was supported by funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) for the Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy).
PY - 2011/4/30
Y1 - 2011/4/30
N2 - Electrospinning is a versatile technique in tissue engineering for the production of scaffolds. To guide tissue development, scaffolds must provide specific biochemical, structural and mechanical cues to cells and deliver them in a controlled fashion over time. Electrospun scaffold design thus includes aspects of both controlled release and structural cues. Controlled multicomponent and multiphasic drug delivery can be achieved by the careful application and combination of novel electrospinning techniques, i.e., emulsion and co-axial electrospinning. Drug distribution and polymer properties influence the resulting release kinetics. Pore size is far more relevant as a structural parameter than previously recognized. It enables cell proliferation and ingrowth, whereas fiber diameter predominantly influences cell fate. Both parameters can be exploited by combining multiple fiber types in the form of multifiber and multilayer scaffolds. Such scaffolds are required to reproduce more complex tissue structures.
AB - Electrospinning is a versatile technique in tissue engineering for the production of scaffolds. To guide tissue development, scaffolds must provide specific biochemical, structural and mechanical cues to cells and deliver them in a controlled fashion over time. Electrospun scaffold design thus includes aspects of both controlled release and structural cues. Controlled multicomponent and multiphasic drug delivery can be achieved by the careful application and combination of novel electrospinning techniques, i.e., emulsion and co-axial electrospinning. Drug distribution and polymer properties influence the resulting release kinetics. Pore size is far more relevant as a structural parameter than previously recognized. It enables cell proliferation and ingrowth, whereas fiber diameter predominantly influences cell fate. Both parameters can be exploited by combining multiple fiber types in the form of multifiber and multilayer scaffolds. Such scaffolds are required to reproduce more complex tissue structures.
KW - Cell ingrowth
KW - Cell proliferation
KW - Electrospinning
KW - Fiber diameter
KW - Pore size
KW - Porosity
KW - Protein delivery
KW - Release kinetics
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=79957673714&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2010.12.002
DO - 10.1016/j.addr.2010.12.002
M3 - Review article
C2 - 21145932
AN - SCOPUS:79957673714
VL - 63
SP - 209
EP - 220
JO - Advanced drug delivery reviews
JF - Advanced drug delivery reviews
SN - 0169-409X
IS - 4-5
ER -