Details
| Original language | English |
|---|---|
| Pages | 153-156 |
| Number of pages | 4 |
| Publication status | Published - 16 May 2018 |
| Event | 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference - Anaheim, United States Duration: 13 May 2018 → 16 May 2018 |
Conference
| Conference | 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference |
|---|---|
| Country/Territory | United States |
| City | Anaheim |
| Period | 13 May 2018 → 16 May 2018 |
Abstract
Monitoring of water samples in remote locations and the developing world is crucial to protect people from infectious diseases primary caused by enteric pathogens. Routine pathogen detection, which is usually based on cell cultivation methods, is labor intense and time consuming. Some pathogens may cause diseases with rapid-evolution symptoms. Therefore, fast, sensitive and reliable detection of pathogen contamination is of great significance. Biosensor technologies are currently under intense investigation for detecting pathogens responsible for diseases in various fields. For point of sample applications, the detection platform should be cost-effective, fast, sensitive, easy to use, stable under a wide range of operating conditions, and portable. Nucleic acid-based biosensors show great potential for integration in a lab-on-a-chip (LOC) for selective and sensitive detection of target microorganisms. Especially schemes employing electromechanical signal transduction are simple and straightforward, e.g. quartz crystal microbalances (QCM). In this work, we show two different QCM-based detection schemes: a proof-of-concept study for indirect detection of Escherichia coli (E. coli) via matching of characteristic DNA sequences and a direct capture biosensor utilizing an E. coli specific aptamer.
Keywords
- Aptamer, Biosensor, Pathogen detection, Quartz crystal microbalance
ASJC Scopus subject areas
Sustainable Development Goals
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2018. 153-156 Paper presented at 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference, Anaheim, United States.
Research output: Contribution to conference › Paper › Research › peer review
}
TY - CONF
T1 - Electromechanical detection of pathogens with self-assembled nucleic acid biosensors
AU - Urmann, Katharina
AU - Bahnemann, Janina
AU - Chikneyan, Zaini
AU - Kasmaee, Laleh M.
AU - Hoffmann, Michael R.
PY - 2018/5/16
Y1 - 2018/5/16
N2 - Monitoring of water samples in remote locations and the developing world is crucial to protect people from infectious diseases primary caused by enteric pathogens. Routine pathogen detection, which is usually based on cell cultivation methods, is labor intense and time consuming. Some pathogens may cause diseases with rapid-evolution symptoms. Therefore, fast, sensitive and reliable detection of pathogen contamination is of great significance. Biosensor technologies are currently under intense investigation for detecting pathogens responsible for diseases in various fields. For point of sample applications, the detection platform should be cost-effective, fast, sensitive, easy to use, stable under a wide range of operating conditions, and portable. Nucleic acid-based biosensors show great potential for integration in a lab-on-a-chip (LOC) for selective and sensitive detection of target microorganisms. Especially schemes employing electromechanical signal transduction are simple and straightforward, e.g. quartz crystal microbalances (QCM). In this work, we show two different QCM-based detection schemes: a proof-of-concept study for indirect detection of Escherichia coli (E. coli) via matching of characteristic DNA sequences and a direct capture biosensor utilizing an E. coli specific aptamer.
AB - Monitoring of water samples in remote locations and the developing world is crucial to protect people from infectious diseases primary caused by enteric pathogens. Routine pathogen detection, which is usually based on cell cultivation methods, is labor intense and time consuming. Some pathogens may cause diseases with rapid-evolution symptoms. Therefore, fast, sensitive and reliable detection of pathogen contamination is of great significance. Biosensor technologies are currently under intense investigation for detecting pathogens responsible for diseases in various fields. For point of sample applications, the detection platform should be cost-effective, fast, sensitive, easy to use, stable under a wide range of operating conditions, and portable. Nucleic acid-based biosensors show great potential for integration in a lab-on-a-chip (LOC) for selective and sensitive detection of target microorganisms. Especially schemes employing electromechanical signal transduction are simple and straightforward, e.g. quartz crystal microbalances (QCM). In this work, we show two different QCM-based detection schemes: a proof-of-concept study for indirect detection of Escherichia coli (E. coli) via matching of characteristic DNA sequences and a direct capture biosensor utilizing an E. coli specific aptamer.
KW - Aptamer
KW - Biosensor
KW - Pathogen detection
KW - Quartz crystal microbalance
UR - http://www.scopus.com/inward/record.url?scp=85050860917&partnerID=8YFLogxK
M3 - Paper
AN - SCOPUS:85050860917
SP - 153
EP - 156
T2 - 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference
Y2 - 13 May 2018 through 16 May 2018
ER -