Details
| Original language | English |
|---|---|
| Pages (from-to) | 4815-4825 |
| Number of pages | 11 |
| Journal | Acta biomaterialia |
| Volume | 9 |
| Issue number | 1 |
| Publication status | Published - 17 Aug 2012 |
Abstract
Nanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.
Keywords
- Animal model, Drug release, Infection, Middle ear, Nanoporous
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Materials Science(all)
- Biomaterials
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Engineering(all)
- Biomedical Engineering
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Acta biomaterialia, Vol. 9, No. 1, 17.08.2012, p. 4815-4825.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics
T2 - An animal study in rabbits
AU - Lensing, Rebecca
AU - Bleich, André
AU - Smoczek, Anna
AU - Glage, Silke
AU - Ehlert, Nina
AU - Luessenhop, Tammo
AU - Behrens, Peter
AU - Müller, Peter Paul
AU - Kietzmann, Manfred
AU - Stieve, Martin
N1 - Funding information: This work was supported by the German Research Foundation (DFG-SFB Collaborative Research Centre 599).
PY - 2012/8/17
Y1 - 2012/8/17
N2 - Nanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.
AB - Nanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.
KW - Animal model
KW - Drug release
KW - Infection
KW - Middle ear
KW - Nanoporous
UR - http://www.scopus.com/inward/record.url?scp=84870240626&partnerID=8YFLogxK
U2 - 10.1016/j.actbio.2012.08.016
DO - 10.1016/j.actbio.2012.08.016
M3 - Article
C2 - 22906623
AN - SCOPUS:84870240626
VL - 9
SP - 4815
EP - 4825
JO - Acta biomaterialia
JF - Acta biomaterialia
SN - 1742-7061
IS - 1
ER -