Details
| Original language | English |
|---|---|
| Article number | e40189 |
| Journal | Heliyon |
| Volume | 10 |
| Issue number | 22 |
| Early online date | 7 Nov 2024 |
| Publication status | E-pub ahead of print - 7 Nov 2024 |
Abstract
The relationship between obesity and the conformational structure of hemoglobin (Hb) has not been extensively investigated. This study aims to elucidate the dielectric parameters that distinguish the Hb molecule under obese conditions and following treatment with goldenberry (GB) extract, compared to a control group. The dielectric parameters analyzed include the loss factor (D), relaxation time (τ), dielectric increment (Δε), relative permittivity (έ), dielectric loss (ε"), conductivity (σ), and Cole-Cole parameters (α), measured across a frequency range of 20 Hz to 3 MHz. Significant differences in dielectric parameters were observed between obese rats and those treated with GB extract. Obese rats exhibited higher dielectric values compared to the control group, while rats treated with low and high doses of GB extract showed marked changes in Hb conformational structure. This study highlights the potential of dielectric parameters as biophysical markers for detecting hemoglobin conformational changes. Furthermore, it suggests that dielectric behavior could serve as an early indicator for assessing the severity of obesity and its related complications.
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In: Heliyon, Vol. 10, No. 22, e40189, 30.11.2024.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Efficacy of goldenberry in improving obesity-induced hemoglobin conformational structure changes in wistar rats
T2 - A biophysical perspective
AU - Abdelmottaleb Moussa, Sherif A.
AU - Aziz, Samir W.
AU - Bashandy, Samir A.
AU - elbaset, Marawan Abd
AU - Abd El-Latif, Noha A.
AU - Afifi, Sherif M.
AU - Esatbeyoglu, Tuba
AU - El Toumy, Sayed A.
AU - Salib, Josline Y.
N1 - Publisher Copyright: © 2024
PY - 2024/11/7
Y1 - 2024/11/7
N2 - The relationship between obesity and the conformational structure of hemoglobin (Hb) has not been extensively investigated. This study aims to elucidate the dielectric parameters that distinguish the Hb molecule under obese conditions and following treatment with goldenberry (GB) extract, compared to a control group. The dielectric parameters analyzed include the loss factor (D), relaxation time (τ), dielectric increment (Δε), relative permittivity (έ), dielectric loss (ε"), conductivity (σ), and Cole-Cole parameters (α), measured across a frequency range of 20 Hz to 3 MHz. Significant differences in dielectric parameters were observed between obese rats and those treated with GB extract. Obese rats exhibited higher dielectric values compared to the control group, while rats treated with low and high doses of GB extract showed marked changes in Hb conformational structure. This study highlights the potential of dielectric parameters as biophysical markers for detecting hemoglobin conformational changes. Furthermore, it suggests that dielectric behavior could serve as an early indicator for assessing the severity of obesity and its related complications.
AB - The relationship between obesity and the conformational structure of hemoglobin (Hb) has not been extensively investigated. This study aims to elucidate the dielectric parameters that distinguish the Hb molecule under obese conditions and following treatment with goldenberry (GB) extract, compared to a control group. The dielectric parameters analyzed include the loss factor (D), relaxation time (τ), dielectric increment (Δε), relative permittivity (έ), dielectric loss (ε"), conductivity (σ), and Cole-Cole parameters (α), measured across a frequency range of 20 Hz to 3 MHz. Significant differences in dielectric parameters were observed between obese rats and those treated with GB extract. Obese rats exhibited higher dielectric values compared to the control group, while rats treated with low and high doses of GB extract showed marked changes in Hb conformational structure. This study highlights the potential of dielectric parameters as biophysical markers for detecting hemoglobin conformational changes. Furthermore, it suggests that dielectric behavior could serve as an early indicator for assessing the severity of obesity and its related complications.
UR - http://www.scopus.com/inward/record.url?scp=85208677737&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2024.e40189
DO - 10.1016/j.heliyon.2024.e40189
M3 - Article
AN - SCOPUS:85208677737
VL - 10
JO - Heliyon
JF - Heliyon
SN - 2405-8440
IS - 22
M1 - e40189
ER -