Details
| Original language | English |
|---|---|
| Pages (from-to) | 558-566 |
| Number of pages | 9 |
| Journal | International Journal of Phytomedicine |
| Volume | 8 |
| Issue number | 4 |
| Publication status | Published - 2017 |
Abstract
Traditional use, chemical constituents, and results of prior animal studies indicate alleviating effects of Opuntiaficus-indica flowers extract on subsyndromalfatigue symptoms in humans 50 healthy subjects of either gender aged 30 to 60 years with subsyndromal fatigue were enrolled in this open-label monocentric single arm proof-of-principle study. 500mg of a hydro-alcoholic extract from Opuntiaficus-indica flowers were administered daily over 8 weeks. Mental and psychic function parameters were assessed by numerical analogue scale of Subjective Fatigue Symptoms, Multidimensional Fatigue Inventory 20, Sheehan Disability Scale, Short Form Health Survey 36, Fatigue Impact Scale, and Global Self-Assessment. Also, health-related incidents, laboratory parameters and vital signs were measured during the intervention period. Improvement of fatigue symptoms could be shown in most measurements after week 1and continued further throughout the trial. 70.0% of subjects reported global improvement of their complaints at end of study. A consistent and positive effect of Opuntiaficus-indica flowers extract on symptoms of fatigue could be demonstrated. Improvement in all mental and psychic functions could be measured, most of them statistically significant.
Keywords
- Fatigue, Flavonoids, Mental and psychic function parameters, Opuntiaficus-indica, Proof-of-Principle study, Sokatin
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Medicine(all)
- Complementary and alternative medicine
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In: International Journal of Phytomedicine, Vol. 8, No. 4, 2017, p. 558-566.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Effects of Opuntia ficus-indica flower extract WS 1261 on mental and psychic function in subsyndromal fatigue - a pilot study
AU - Kressel, G.
AU - Willers, J.
AU - Kohrs, H.
AU - Zimmermann, Andrea
AU - Klement, S.
AU - Dienel, A.
AU - Hahn, Andreas
N1 - Publisher Copyright: © 2016, Advanced Research Journals. All rights reserved. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - Traditional use, chemical constituents, and results of prior animal studies indicate alleviating effects of Opuntiaficus-indica flowers extract on subsyndromalfatigue symptoms in humans 50 healthy subjects of either gender aged 30 to 60 years with subsyndromal fatigue were enrolled in this open-label monocentric single arm proof-of-principle study. 500mg of a hydro-alcoholic extract from Opuntiaficus-indica flowers were administered daily over 8 weeks. Mental and psychic function parameters were assessed by numerical analogue scale of Subjective Fatigue Symptoms, Multidimensional Fatigue Inventory 20, Sheehan Disability Scale, Short Form Health Survey 36, Fatigue Impact Scale, and Global Self-Assessment. Also, health-related incidents, laboratory parameters and vital signs were measured during the intervention period. Improvement of fatigue symptoms could be shown in most measurements after week 1and continued further throughout the trial. 70.0% of subjects reported global improvement of their complaints at end of study. A consistent and positive effect of Opuntiaficus-indica flowers extract on symptoms of fatigue could be demonstrated. Improvement in all mental and psychic functions could be measured, most of them statistically significant.
AB - Traditional use, chemical constituents, and results of prior animal studies indicate alleviating effects of Opuntiaficus-indica flowers extract on subsyndromalfatigue symptoms in humans 50 healthy subjects of either gender aged 30 to 60 years with subsyndromal fatigue were enrolled in this open-label monocentric single arm proof-of-principle study. 500mg of a hydro-alcoholic extract from Opuntiaficus-indica flowers were administered daily over 8 weeks. Mental and psychic function parameters were assessed by numerical analogue scale of Subjective Fatigue Symptoms, Multidimensional Fatigue Inventory 20, Sheehan Disability Scale, Short Form Health Survey 36, Fatigue Impact Scale, and Global Self-Assessment. Also, health-related incidents, laboratory parameters and vital signs were measured during the intervention period. Improvement of fatigue symptoms could be shown in most measurements after week 1and continued further throughout the trial. 70.0% of subjects reported global improvement of their complaints at end of study. A consistent and positive effect of Opuntiaficus-indica flowers extract on symptoms of fatigue could be demonstrated. Improvement in all mental and psychic functions could be measured, most of them statistically significant.
KW - Fatigue
KW - Flavonoids
KW - Mental and psychic function parameters
KW - Opuntiaficus-indica
KW - Proof-of-Principle study
KW - Sokatin
UR - http://www.scopus.com/inward/record.url?scp=85019513342&partnerID=8YFLogxK
U2 - 10.5138/09750185.1909
DO - 10.5138/09750185.1909
M3 - Article
VL - 8
SP - 558
EP - 566
JO - International Journal of Phytomedicine
JF - International Journal of Phytomedicine
SN - 0975-0185
IS - 4
ER -