Details
| Original language | English |
|---|---|
| Pages (from-to) | 4169-4172 |
| Number of pages | 4 |
| Journal | Biomacromolecules |
| Volume | 12 |
| Issue number | 11 |
| Early online date | 28 Sept 2011 |
| Publication status | Published - 14 Nov 2011 |
| Externally published | Yes |
Abstract
Polymer brushes show great promise in next-generation antibiofouling surfaces. Here, we have studied the influence of polymer brush architecture on protein resistance. By carefully optimizing reaction conditions, we were able to polymerize oligoglycerol-based brushes with sterically demanding linear or dendronized side chains on gold surfaces. Protein adsorption from serum and plasma was analyzed by surface plasmon resonance. Our findings reveal a pronounced dependence of biofouling on brush architecture. Bulky yet flexible side chains as in dendronized brushes provide an ideal environment to repel protein-possibly through formation of a hydration layer, which can be further enhanced by presenting free hydroxyl groups on the polymer brushes. A deeper understanding of how brush architecture influences protein resistance will ultimately enable fabrication of surface coatings tailored to specific requirements in biomedical applications.
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Materials Science(all)
- Biomaterials
- Materials Science(all)
- Polymers and Plastics
- Materials Science(all)
- Materials Chemistry
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In: Biomacromolecules, Vol. 12, No. 11, 14.11.2011, p. 4169-4172.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Effect of polymer brush architecture on antibiofouling properties
AU - Gunkel, Gesine
AU - Weinhart, Marie
AU - Becherer, Tobias
AU - Haag, Rainer
AU - Huck, Wilhelm T.S.
PY - 2011/11/14
Y1 - 2011/11/14
N2 - Polymer brushes show great promise in next-generation antibiofouling surfaces. Here, we have studied the influence of polymer brush architecture on protein resistance. By carefully optimizing reaction conditions, we were able to polymerize oligoglycerol-based brushes with sterically demanding linear or dendronized side chains on gold surfaces. Protein adsorption from serum and plasma was analyzed by surface plasmon resonance. Our findings reveal a pronounced dependence of biofouling on brush architecture. Bulky yet flexible side chains as in dendronized brushes provide an ideal environment to repel protein-possibly through formation of a hydration layer, which can be further enhanced by presenting free hydroxyl groups on the polymer brushes. A deeper understanding of how brush architecture influences protein resistance will ultimately enable fabrication of surface coatings tailored to specific requirements in biomedical applications.
AB - Polymer brushes show great promise in next-generation antibiofouling surfaces. Here, we have studied the influence of polymer brush architecture on protein resistance. By carefully optimizing reaction conditions, we were able to polymerize oligoglycerol-based brushes with sterically demanding linear or dendronized side chains on gold surfaces. Protein adsorption from serum and plasma was analyzed by surface plasmon resonance. Our findings reveal a pronounced dependence of biofouling on brush architecture. Bulky yet flexible side chains as in dendronized brushes provide an ideal environment to repel protein-possibly through formation of a hydration layer, which can be further enhanced by presenting free hydroxyl groups on the polymer brushes. A deeper understanding of how brush architecture influences protein resistance will ultimately enable fabrication of surface coatings tailored to specific requirements in biomedical applications.
UR - http://www.scopus.com/inward/record.url?scp=81255185800&partnerID=8YFLogxK
U2 - 10.1021/bm200943m
DO - 10.1021/bm200943m
M3 - Article
C2 - 21932841
AN - SCOPUS:81255185800
VL - 12
SP - 4169
EP - 4172
JO - Biomacromolecules
JF - Biomacromolecules
SN - 1525-7797
IS - 11
ER -