Details
| Original language | English |
|---|---|
| Pages (from-to) | 129-133 |
| Number of pages | 5 |
| Journal | Journal of functional foods |
| Volume | 3 |
| Issue number | 2 |
| Publication status | Published - Apr 2011 |
Abstract
Fish oil capsules with gastric acid resistant coatings have been shown to lower undesirable side effects. We compared the eicosapentaenoic acid (EPA). +. docosahexaenoic acid (DHA) uptake from uncoated and coated fish oil capsules. In a double-blinded crossover trial 12 healthy young men (mean age 31. years) were randomized to 1680. mg EPA. +. DHA as triacylglycerols in uncoated or coated fish oil capsules. Fatty acid levels were analyzed in plasma phospholipids at baseline and 2, 4, 6, 8, 24, 48 and 72. h after capsule ingestion. Statistical group comparisons on the basis of area under the curve values revealed no significant differences for EPA, DHA and total n-3 fatty acid levels between the different capsule formulations. In conclusion, this nutrikinetic study indicates that coating of fish oil capsules with a gastric acid resistant layer has no influence on the bioavailability of EPA. +. DHA.
Keywords
- Absorption, Bioavailability, DHA, Enteric coating, EPA, Omega-3 fatty acids
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Food Science
- Medicine(all)
- Medicine (miscellaneous)
- Nursing(all)
- Nutrition and Dietetics
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In: Journal of functional foods, Vol. 3, No. 2, 04.2011, p. 129-133.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Effect of gastric acid resistant coating of fish oil capsules on intestinal uptake of eicosapentaenoic acid and docosahexaenoic acid
AU - Schneider, Inga
AU - Schuchardt, Jan Philipp
AU - Meyer, Henrike
AU - Hahn, Andreas
PY - 2011/4
Y1 - 2011/4
N2 - Fish oil capsules with gastric acid resistant coatings have been shown to lower undesirable side effects. We compared the eicosapentaenoic acid (EPA). +. docosahexaenoic acid (DHA) uptake from uncoated and coated fish oil capsules. In a double-blinded crossover trial 12 healthy young men (mean age 31. years) were randomized to 1680. mg EPA. +. DHA as triacylglycerols in uncoated or coated fish oil capsules. Fatty acid levels were analyzed in plasma phospholipids at baseline and 2, 4, 6, 8, 24, 48 and 72. h after capsule ingestion. Statistical group comparisons on the basis of area under the curve values revealed no significant differences for EPA, DHA and total n-3 fatty acid levels between the different capsule formulations. In conclusion, this nutrikinetic study indicates that coating of fish oil capsules with a gastric acid resistant layer has no influence on the bioavailability of EPA. +. DHA.
AB - Fish oil capsules with gastric acid resistant coatings have been shown to lower undesirable side effects. We compared the eicosapentaenoic acid (EPA). +. docosahexaenoic acid (DHA) uptake from uncoated and coated fish oil capsules. In a double-blinded crossover trial 12 healthy young men (mean age 31. years) were randomized to 1680. mg EPA. +. DHA as triacylglycerols in uncoated or coated fish oil capsules. Fatty acid levels were analyzed in plasma phospholipids at baseline and 2, 4, 6, 8, 24, 48 and 72. h after capsule ingestion. Statistical group comparisons on the basis of area under the curve values revealed no significant differences for EPA, DHA and total n-3 fatty acid levels between the different capsule formulations. In conclusion, this nutrikinetic study indicates that coating of fish oil capsules with a gastric acid resistant layer has no influence on the bioavailability of EPA. +. DHA.
KW - Absorption
KW - Bioavailability
KW - DHA
KW - Enteric coating
KW - EPA
KW - Omega-3 fatty acids
UR - http://www.scopus.com/inward/record.url?scp=79954996251&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2011.03.001
DO - 10.1016/j.jff.2011.03.001
M3 - Article
AN - SCOPUS:79954996251
VL - 3
SP - 129
EP - 133
JO - Journal of functional foods
JF - Journal of functional foods
SN - 1756-4646
IS - 2
ER -