TY - JOUR

T1 - Dipyridamole embedded in Polycaprolactone fibers prepared by coaxial electrospinning as a novel drug delivery system

AU - Repanas, Alexandros

AU - Glasmacher, Birgit

N1 - Funding Information: This research was granted by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) by the Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy, DFG EXC 62/1 ). The authors express their sincere gratitude to fellow researchers Anamika Chatterjee MSc, Marc Müller MSc and Oleksandr Gryshkov PhD, from the Institute for Multiphase Processes, Leibniz Universität Hannover, Germany, as well as to Sofia Andriopoulou MSc, from the Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Germany for their contribution to the data analysis and editing the manuscript.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Numerous clinical trials have indicated that an anti-platelet treatment can reduce the risk of recurrent stroke events. Dipyridamole (DIP) is a pharmaceutical compound known to induce platelet aggregation inhibition. Drug delivery systems (DDSs) made of biodegradable polymers can be created using electrospinning, which is a versatile and cost-effective technique that can produce fibrous structures, capable of sustained drug release. A novel DDS made of Polycaprolactone (PCL) with encapsulated DIP was prepared by coaxial electrospinning. The main aim of the current study was to evaluate how different concentrations of PCL in the core and shell solutions and different core concentrations of DIP, affect the fibers' structural and physical properties. Results indicated that the electrical conductivity of the solutions was influenced mainly by the concentration of DIP and less by PCL. Moreover, the average fiber diameter was altered by the concentration of both PCL and DIP, which consequently had an impact on the surface hydrophilicity. Finally, the fibers' encapsulation efficiency and the cumulative drug release were studied and correlated to the concentrations of the drug and the polymer. The obtained data was fitted to a known kinetics model in order to evaluate their release mechanism, which was Fickian diffusion in all cases.

AB - Numerous clinical trials have indicated that an anti-platelet treatment can reduce the risk of recurrent stroke events. Dipyridamole (DIP) is a pharmaceutical compound known to induce platelet aggregation inhibition. Drug delivery systems (DDSs) made of biodegradable polymers can be created using electrospinning, which is a versatile and cost-effective technique that can produce fibrous structures, capable of sustained drug release. A novel DDS made of Polycaprolactone (PCL) with encapsulated DIP was prepared by coaxial electrospinning. The main aim of the current study was to evaluate how different concentrations of PCL in the core and shell solutions and different core concentrations of DIP, affect the fibers' structural and physical properties. Results indicated that the electrical conductivity of the solutions was influenced mainly by the concentration of DIP and less by PCL. Moreover, the average fiber diameter was altered by the concentration of both PCL and DIP, which consequently had an impact on the surface hydrophilicity. Finally, the fibers' encapsulation efficiency and the cumulative drug release were studied and correlated to the concentrations of the drug and the polymer. The obtained data was fitted to a known kinetics model in order to evaluate their release mechanism, which was Fickian diffusion in all cases.

KW - Biomaterials

KW - Coaxial electrospinning

KW - Controlled drug delivery

KW - Dipyridamole

KW - Polycaprolactone

UR - http://www.scopus.com/inward/record.url?scp=84942316618&partnerID=8YFLogxK

U2 - 10.1016/j.jddst.2015.07.001

DO - 10.1016/j.jddst.2015.07.001

M3 - Article

AN - SCOPUS:84942316618

VL - 29

SP - 132

EP - 142

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

ER -