Details
| Original language | English |
|---|---|
| Article number | 115067 |
| Number of pages | 18 |
| Journal | Cell reports |
| Volume | 43 |
| Issue number | 12 |
| Early online date | 13 Dec 2024 |
| Publication status | Published - 24 Dec 2024 |
Abstract
Diet significantly influences the human gut microbiota, a key player in health. We analyzed shotgun metagenomic sequencing data from healthy individuals with long-term dietary patterns—vegan, flexitarian, or omnivore—and included detailed dietary surveys and blood biomarkers. Dietary patterns notably affected the bacterial community composition by altering the relative abundances of certain species but had a minimal impact on microbial functional repertoires. However, diet influenced microbial functionality at the strain level, with diet type linked to strain genetic variations. We also found molecular signatures of selective pressure in species enriched by specific diets. Notably, species enriched in omnivores exhibited stronger positive selection, such as multiple iron-regulating genes in the meat-favoring bacterium Odoribacter splanchnicus, an effect that was also validated in independent cohorts. Our findings offer insights into how diet shapes species and genetic diversity in the human gut microbiota.
Keywords
- CP: Microbiology, diet, functionality, genetic variations, gut, microbiota, positive selection, shotgun metagenomics, strain diversity
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- General Biochemistry,Genetics and Molecular Biology
Sustainable Development Goals
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In: Cell reports, Vol. 43, No. 12, 115067, 24.12.2024.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup
AU - Huang, Kun D.
AU - Müller, Mattea
AU - Sivapornnukul, Pavaret
AU - Bielecka, Agata Anna
AU - Amend, Lena
AU - Tawk, Caroline
AU - Hahn, Andreas
AU - Lesker, Till Robin
AU - Strowig, Till
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024/12/24
Y1 - 2024/12/24
N2 - Diet significantly influences the human gut microbiota, a key player in health. We analyzed shotgun metagenomic sequencing data from healthy individuals with long-term dietary patterns—vegan, flexitarian, or omnivore—and included detailed dietary surveys and blood biomarkers. Dietary patterns notably affected the bacterial community composition by altering the relative abundances of certain species but had a minimal impact on microbial functional repertoires. However, diet influenced microbial functionality at the strain level, with diet type linked to strain genetic variations. We also found molecular signatures of selective pressure in species enriched by specific diets. Notably, species enriched in omnivores exhibited stronger positive selection, such as multiple iron-regulating genes in the meat-favoring bacterium Odoribacter splanchnicus, an effect that was also validated in independent cohorts. Our findings offer insights into how diet shapes species and genetic diversity in the human gut microbiota.
AB - Diet significantly influences the human gut microbiota, a key player in health. We analyzed shotgun metagenomic sequencing data from healthy individuals with long-term dietary patterns—vegan, flexitarian, or omnivore—and included detailed dietary surveys and blood biomarkers. Dietary patterns notably affected the bacterial community composition by altering the relative abundances of certain species but had a minimal impact on microbial functional repertoires. However, diet influenced microbial functionality at the strain level, with diet type linked to strain genetic variations. We also found molecular signatures of selective pressure in species enriched by specific diets. Notably, species enriched in omnivores exhibited stronger positive selection, such as multiple iron-regulating genes in the meat-favoring bacterium Odoribacter splanchnicus, an effect that was also validated in independent cohorts. Our findings offer insights into how diet shapes species and genetic diversity in the human gut microbiota.
KW - CP: Microbiology
KW - diet
KW - functionality
KW - genetic variations
KW - gut
KW - microbiota
KW - positive selection
KW - shotgun metagenomics
KW - strain diversity
UR - http://www.scopus.com/inward/record.url?scp=85211632140&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2024.115067
DO - 10.1016/j.celrep.2024.115067
M3 - Article
AN - SCOPUS:85211632140
VL - 43
JO - Cell reports
JF - Cell reports
SN - 2639-1856
IS - 12
M1 - 115067
ER -