Details
| Original language | English |
|---|---|
| Article number | e202303843 |
| Number of pages | 12 |
| Journal | Chemistry - a European journal |
| Volume | 30 |
| Issue number | 22 |
| Early online date | 13 Jan 2024 |
| Publication status | Published - 16 Apr 2024 |
Abstract
The development of hydrogels based on dextrans, pullulan and lentinan to be used in biomedical applications including tissue engineering is reported. Despite the fact that selected polysaccharides such as hyaluronic acid are well established, little is known, how these polysaccharides can be chemically modified to create hydrogels under controlled conditions. In this study we present a small library of chemically modified polysaccharides which are used for a divergent approach to achieve biomedical relevant hydrogels. In this case the crosslinking is based on thio ether formation between thiol modified donor and vinylsulfone or maleimide modified acceptor components. Successful synthesis of the linker systems and coupling at the polysaccharides, hydrogel formation takes place under physiological conditions. We extended the study by coupling small molecules like adhesion factors for increasing cell compatibility as well as a dye for further studies. The different hydrogels were studied to their rheological properties, water uptake, their permeability, biodegrability and their cytotoxicity.
Keywords
- click chemistry, dextran, hydrogels, lentinan, pullulan
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
- Chemistry(all)
- Organic Chemistry
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In: Chemistry - a European journal, Vol. 30, No. 22, e202303843, 16.04.2024.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Dextrans, Pullulan and Lentinan, New Scaffold Materials for Use as Hydrogels in Tissue Engineering
AU - Lienig, Pascal
AU - Banerjee, Samhita
AU - Kenneweg, Franziska
AU - Thum, Thomas
AU - Kirschning, Andreas
AU - Dräger, Gerald
N1 - Funding Information: The work was funded by the Deutsche Forschungsgemeinschaft (Cluster of Excellence REBIRTH; “From Regenerative Biology to Reconstructive Therapy” EXC 62). Additionally, this work has been carried out as an integral part of the BIOFABRICATION FOR NIFE Initiative, which is financially supported by the ministry of Lower Saxony and the Volkswagen Stiftung (NIFE is the Lower Saxony Center for Biomedical Engineering, Implant Research and Development, a joint translational research center of the Hannover Medical School, the Leibniz Universität Hannover, the University of Veterinary Medicine Hannover and the Laser Center Hannover. Open Access funding enabled and organized by Projekt DEAL.
PY - 2024/4/16
Y1 - 2024/4/16
N2 - The development of hydrogels based on dextrans, pullulan and lentinan to be used in biomedical applications including tissue engineering is reported. Despite the fact that selected polysaccharides such as hyaluronic acid are well established, little is known, how these polysaccharides can be chemically modified to create hydrogels under controlled conditions. In this study we present a small library of chemically modified polysaccharides which are used for a divergent approach to achieve biomedical relevant hydrogels. In this case the crosslinking is based on thio ether formation between thiol modified donor and vinylsulfone or maleimide modified acceptor components. Successful synthesis of the linker systems and coupling at the polysaccharides, hydrogel formation takes place under physiological conditions. We extended the study by coupling small molecules like adhesion factors for increasing cell compatibility as well as a dye for further studies. The different hydrogels were studied to their rheological properties, water uptake, their permeability, biodegrability and their cytotoxicity.
AB - The development of hydrogels based on dextrans, pullulan and lentinan to be used in biomedical applications including tissue engineering is reported. Despite the fact that selected polysaccharides such as hyaluronic acid are well established, little is known, how these polysaccharides can be chemically modified to create hydrogels under controlled conditions. In this study we present a small library of chemically modified polysaccharides which are used for a divergent approach to achieve biomedical relevant hydrogels. In this case the crosslinking is based on thio ether formation between thiol modified donor and vinylsulfone or maleimide modified acceptor components. Successful synthesis of the linker systems and coupling at the polysaccharides, hydrogel formation takes place under physiological conditions. We extended the study by coupling small molecules like adhesion factors for increasing cell compatibility as well as a dye for further studies. The different hydrogels were studied to their rheological properties, water uptake, their permeability, biodegrability and their cytotoxicity.
KW - click chemistry
KW - dextran
KW - hydrogels
KW - lentinan
KW - pullulan
UR - http://www.scopus.com/inward/record.url?scp=85186547626&partnerID=8YFLogxK
U2 - 10.1002/chem.202303843
DO - 10.1002/chem.202303843
M3 - Article
AN - SCOPUS:85186547626
VL - 30
JO - Chemistry - a European journal
JF - Chemistry - a European journal
SN - 0947-6539
IS - 22
M1 - e202303843
ER -