Details
| Original language | English |
|---|---|
| Pages (from-to) | 81-100 |
| Number of pages | 20 |
| Journal | Lecture Notes in Applied and Computational Mechanics (Print) |
| Volume | 74 |
| Publication status | Published - 1 Jan 2015 |
Abstract
Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most biological grafts is initially not sufficient for left ventricular applications. Implants that mechanically support these grafts and gradually lose their function as the graft develops its strength are a possible solution. We are developing magnesium alloy scaffolds for this purpose. The finite element method was used to perform simulations wherein scaffolds are deformed according to the heart movement. This allows us to identify highly stressed regions within the implant that need design changes. Preformed scaffolds were determined to have significantly lower stresses in comparison to flat ones. The method of tensile triangles suggests shape changes for notable stress reduction. Furthermore, new scaffold shapes were developed and simulated. Two of them are recommended for further examinations through in vitro and in vivo tests. A completely new alternative scaffold concept is also proposed.
Keywords
- FEM, Heart attack, LA63, Left ventricle, Numerical simulation, Supporting structure, Tensile triangles, Tissue substitution
ASJC Scopus subject areas
- Engineering(all)
- Mechanical Engineering
- Computer Science(all)
- Computational Theory and Mathematics
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In: Lecture Notes in Applied and Computational Mechanics (Print), Vol. 74, 01.01.2015, p. 81-100.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Development of Magnesium Alloy Scaffolds to Support Biological Myocardial Grafts
T2 - A Finite Element Investigation
AU - Weidling, Martin
AU - Besdo, Silke
AU - Schilling, Tobias
AU - Bauer, Michael
AU - Hassel, Thomas
AU - Bach, Friedrich Wilhelm
AU - Maier, Hans Jürgen
AU - Lamon, Jacques
AU - Haverich, Axel
AU - Wriggers, Peter
N1 - Funding information: The authors are thankful to the German Research Foundation (DFG) for their financial support. This project is funded within the Collaborative Research Center 599 (SFB 599) and the International Research Training Group 1627 (GRK 1627). Furthermore, we thank Martina Baldrich who developed scaffold shape 7 and Julian Schrader who developed shapes 8–12 in student projects, respectively.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most biological grafts is initially not sufficient for left ventricular applications. Implants that mechanically support these grafts and gradually lose their function as the graft develops its strength are a possible solution. We are developing magnesium alloy scaffolds for this purpose. The finite element method was used to perform simulations wherein scaffolds are deformed according to the heart movement. This allows us to identify highly stressed regions within the implant that need design changes. Preformed scaffolds were determined to have significantly lower stresses in comparison to flat ones. The method of tensile triangles suggests shape changes for notable stress reduction. Furthermore, new scaffold shapes were developed and simulated. Two of them are recommended for further examinations through in vitro and in vivo tests. A completely new alternative scaffold concept is also proposed.
AB - Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most biological grafts is initially not sufficient for left ventricular applications. Implants that mechanically support these grafts and gradually lose their function as the graft develops its strength are a possible solution. We are developing magnesium alloy scaffolds for this purpose. The finite element method was used to perform simulations wherein scaffolds are deformed according to the heart movement. This allows us to identify highly stressed regions within the implant that need design changes. Preformed scaffolds were determined to have significantly lower stresses in comparison to flat ones. The method of tensile triangles suggests shape changes for notable stress reduction. Furthermore, new scaffold shapes were developed and simulated. Two of them are recommended for further examinations through in vitro and in vivo tests. A completely new alternative scaffold concept is also proposed.
KW - FEM
KW - Heart attack
KW - LA63
KW - Left ventricle
KW - Numerical simulation
KW - Supporting structure
KW - Tensile triangles
KW - Tissue substitution
UR - http://www.scopus.com/inward/record.url?scp=84937545255&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-10981-7_6
DO - 10.1007/978-3-319-10981-7_6
M3 - Article
AN - SCOPUS:84937545255
VL - 74
SP - 81
EP - 100
JO - Lecture Notes in Applied and Computational Mechanics (Print)
JF - Lecture Notes in Applied and Computational Mechanics (Print)
SN - 1613-7736
ER -