Details
| Original language | English |
|---|---|
| Pages (from-to) | 3601-3610 |
| Number of pages | 10 |
| Journal | European Journal of Organic Chemistry |
| Issue number | 17 |
| Publication status | Published - 17 Aug 2004 |
Abstract
Heterogeneous catalysis for organic synthesis under continuous-flow conditions becomes possible by a new reactor-based approach. Continuous-flow reactors with a monolithic glass/polymer composite interior are loaded with palladium particles by ion exchange followed by reduction. When incorporated into a continuous-flow setup (PASSflow) this reactor allows the transfer-hydrogenation of alkenes, alkynes, nitro-substituted aromatic compounds and benzyl ethers in the flow-through mode. In addition, the activity of the catalysts is well suited to achieve Suzuki, Sonogashira and Heck cross-coupling reactions in the absence of phosphanes or any other ligands, resulting in a greatly simplified purification. As an extension to this concept a bifunctional support was prepared inside the reactor consisting of Pd particles and an ion-exchange group (hydroxide form). In the Suzuki-Miyaura reaction the reactor serves as a base for immobilisation and activation of the boronic acid as boronate and as a catalyst for promoting the C-C coupling reaction under continuous-flow conditions.
Keywords
- Continuous-flow processes, Heterogeneous catalysis, Hydrogenation, Palladium, Supported catalysts
ASJC Scopus subject areas
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemistry(all)
- Organic Chemistry
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In: European Journal of Organic Chemistry, No. 17, 17.08.2004, p. 3601-3610.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Development of a continuous-flow system for catalysis with palladium(0) particles
AU - Solodenko, Wladimir
AU - Wen, Hongliang
AU - Leue, Stefanie
AU - Stuhlmann, Friedrich
AU - Sourkouni-Argirusi, Georgia
AU - Jas, Gerhard
AU - Schönfeld, Hagen
AU - Kunz, Ulrich
AU - Kirschning, Andreas
PY - 2004/8/17
Y1 - 2004/8/17
N2 - Heterogeneous catalysis for organic synthesis under continuous-flow conditions becomes possible by a new reactor-based approach. Continuous-flow reactors with a monolithic glass/polymer composite interior are loaded with palladium particles by ion exchange followed by reduction. When incorporated into a continuous-flow setup (PASSflow) this reactor allows the transfer-hydrogenation of alkenes, alkynes, nitro-substituted aromatic compounds and benzyl ethers in the flow-through mode. In addition, the activity of the catalysts is well suited to achieve Suzuki, Sonogashira and Heck cross-coupling reactions in the absence of phosphanes or any other ligands, resulting in a greatly simplified purification. As an extension to this concept a bifunctional support was prepared inside the reactor consisting of Pd particles and an ion-exchange group (hydroxide form). In the Suzuki-Miyaura reaction the reactor serves as a base for immobilisation and activation of the boronic acid as boronate and as a catalyst for promoting the C-C coupling reaction under continuous-flow conditions.
AB - Heterogeneous catalysis for organic synthesis under continuous-flow conditions becomes possible by a new reactor-based approach. Continuous-flow reactors with a monolithic glass/polymer composite interior are loaded with palladium particles by ion exchange followed by reduction. When incorporated into a continuous-flow setup (PASSflow) this reactor allows the transfer-hydrogenation of alkenes, alkynes, nitro-substituted aromatic compounds and benzyl ethers in the flow-through mode. In addition, the activity of the catalysts is well suited to achieve Suzuki, Sonogashira and Heck cross-coupling reactions in the absence of phosphanes or any other ligands, resulting in a greatly simplified purification. As an extension to this concept a bifunctional support was prepared inside the reactor consisting of Pd particles and an ion-exchange group (hydroxide form). In the Suzuki-Miyaura reaction the reactor serves as a base for immobilisation and activation of the boronic acid as boronate and as a catalyst for promoting the C-C coupling reaction under continuous-flow conditions.
KW - Continuous-flow processes
KW - Heterogeneous catalysis
KW - Hydrogenation
KW - Palladium
KW - Supported catalysts
UR - http://www.scopus.com/inward/record.url?scp=4544298371&partnerID=8YFLogxK
U2 - 10.1002/ejoc.200400194
DO - 10.1002/ejoc.200400194
M3 - Article
AN - SCOPUS:4544298371
SP - 3601
EP - 3610
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
SN - 1434-193X
IS - 17
ER -