Details
| Original language | English |
|---|---|
| Article number | 20203019 |
| Journal | Current Directions in Biomedical Engineering |
| Volume | 6 |
| Issue number | 3 |
| Publication status | Published - 26 Nov 2020 |
Abstract
Obstructions of the Fallopian tube represent one of the most common reasons for an unfulfilled desire to have children. Microstent technology opens up new therapeutic possibilities to restore the natural lumen of the Fallopian tube within a single treatment. Within the current work we developed a self-expandable biodegradable microstent for gynecological applications. Based on a novel microstent design, prototypes were manufactured from poly-L-lactide tubing by means of fs-laser cutting. Microstent prototypes were characterized morphologically by means of scanning electron microscopy and biaxial laser scanning. As manufactured, a microstents outside diameter of about 2.3 mm and a strut thickness/width of about 114 μm/103 μm was measured. Mechanical characterization of microstents included bending as well as crimping and release behavior. After crimping to a minimum diameter of 0.8 mm and consecutive release, a microstent recovery to a diameter of 1.8 mm was found. Therefore, proof-of-concept for the self-expandable microstent could be successfully provided.
Keywords
- Biodegradable microstent, enabling pregnancy, Fallopian tube occlusion, fertility treatment
ASJC Scopus subject areas
- Engineering(all)
- Biomedical Engineering
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In: Current Directions in Biomedical Engineering, Vol. 6, No. 3, 20203019, 26.11.2020.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Development of a biodegradable microstent for minimally invasive treatment of Fallopian tube occlusions
AU - Dierke, Ariane
AU - Borowski, Finja
AU - Großmann, Swen
AU - Brandt-Wunderlich, Christoph
AU - Matschegewski, Claudia
AU - Rosam, Paula
AU - Stiehm, Michael
AU - Bock, Andrea
AU - Schmitz, Klaus Peter
AU - Siewert, Stefan
AU - Pilz, Nico
AU - Reister, Paul
AU - Schümann, Kerstin
AU - Grabow, Niels
AU - Einenkel, Rebekka
AU - Zygmunt, Marek
AU - Hinze, Ulf
AU - Chichkov, Boris
AU - Keiler, Jonas
AU - Wree, Andreas
PY - 2020/11/26
Y1 - 2020/11/26
N2 - Obstructions of the Fallopian tube represent one of the most common reasons for an unfulfilled desire to have children. Microstent technology opens up new therapeutic possibilities to restore the natural lumen of the Fallopian tube within a single treatment. Within the current work we developed a self-expandable biodegradable microstent for gynecological applications. Based on a novel microstent design, prototypes were manufactured from poly-L-lactide tubing by means of fs-laser cutting. Microstent prototypes were characterized morphologically by means of scanning electron microscopy and biaxial laser scanning. As manufactured, a microstents outside diameter of about 2.3 mm and a strut thickness/width of about 114 μm/103 μm was measured. Mechanical characterization of microstents included bending as well as crimping and release behavior. After crimping to a minimum diameter of 0.8 mm and consecutive release, a microstent recovery to a diameter of 1.8 mm was found. Therefore, proof-of-concept for the self-expandable microstent could be successfully provided.
AB - Obstructions of the Fallopian tube represent one of the most common reasons for an unfulfilled desire to have children. Microstent technology opens up new therapeutic possibilities to restore the natural lumen of the Fallopian tube within a single treatment. Within the current work we developed a self-expandable biodegradable microstent for gynecological applications. Based on a novel microstent design, prototypes were manufactured from poly-L-lactide tubing by means of fs-laser cutting. Microstent prototypes were characterized morphologically by means of scanning electron microscopy and biaxial laser scanning. As manufactured, a microstents outside diameter of about 2.3 mm and a strut thickness/width of about 114 μm/103 μm was measured. Mechanical characterization of microstents included bending as well as crimping and release behavior. After crimping to a minimum diameter of 0.8 mm and consecutive release, a microstent recovery to a diameter of 1.8 mm was found. Therefore, proof-of-concept for the self-expandable microstent could be successfully provided.
KW - Biodegradable microstent
KW - enabling pregnancy
KW - Fallopian tube occlusion
KW - fertility treatment
UR - http://www.scopus.com/inward/record.url?scp=85097314202&partnerID=8YFLogxK
U2 - 10.1515/cdbme-2020-3019
DO - 10.1515/cdbme-2020-3019
M3 - Article
AN - SCOPUS:85097314202
VL - 6
JO - Current Directions in Biomedical Engineering
JF - Current Directions in Biomedical Engineering
IS - 3
M1 - 20203019
ER -