Details
| Original language | English |
|---|---|
| Pages (from-to) | 78-86 |
| Number of pages | 9 |
| Journal | Molecular and Cellular Endocrinology |
| Volume | 348 |
| Issue number | 1 |
| Publication status | Published - 2 Jan 2012 |
| Externally published | Yes |
Abstract
This study was aimed to test our hypothesis that the developing brain operates as an endocrine organ before the establishment of the blood-brain barrier (BBB), in rats up to the first postnatal week. Dopamine (DA) was selected as a marker of the brain endocrine activity. The hypothesis was supported by the observations in rats of: (i) the physiological concentration of DA in peripheral blood of fetuses and neonates, before the BBB establishment, and its drop by prepubertal period, after the BBB development; (ii) a drop of the DA concentration in the brain for 54% and in blood for 74% on the 3rd postnatal day after the intraventricular administration of 50μg of α-methyl-p-tyrosine, an inhibitor of DA synthesis, with no changes in the DA metabolism in peripheral DA-producing organs. Thus, the developing brain is a principal source of circulating DA which is capable of providing an endocrine regulation of peripheral organs and the brain.
Keywords
- Blood-brain barrier, Brain, Development, Dopamine, Neuron, Rat
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Endocrinology
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In: Molecular and Cellular Endocrinology, Vol. 348, No. 1, 02.01.2012, p. 78-86.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Developing brain as an endocrine organ
T2 - Secretion of dopamine
AU - Ugrumov, Michael V.
AU - Saifetyarova, Julia Y.
AU - Lavrentieva, Antonina V.
AU - Sapronova, Anna Y.
N1 - Funding Information: The present study was supported by the following Grants: Program of the Basic Research, Department of Biological Sciences of the Russian Academy of Sciences “Integrative mechanisms of the functional regulations in the organism”, RFBR-08-04-01084 , RFBR-CNRS-07-04-92173 , RFBR-OBR-09-04-13851 , RFBR-CNRS-10-04-93108 , RFBR-11-04-01840 . Copyright: Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/1/2
Y1 - 2012/1/2
N2 - This study was aimed to test our hypothesis that the developing brain operates as an endocrine organ before the establishment of the blood-brain barrier (BBB), in rats up to the first postnatal week. Dopamine (DA) was selected as a marker of the brain endocrine activity. The hypothesis was supported by the observations in rats of: (i) the physiological concentration of DA in peripheral blood of fetuses and neonates, before the BBB establishment, and its drop by prepubertal period, after the BBB development; (ii) a drop of the DA concentration in the brain for 54% and in blood for 74% on the 3rd postnatal day after the intraventricular administration of 50μg of α-methyl-p-tyrosine, an inhibitor of DA synthesis, with no changes in the DA metabolism in peripheral DA-producing organs. Thus, the developing brain is a principal source of circulating DA which is capable of providing an endocrine regulation of peripheral organs and the brain.
AB - This study was aimed to test our hypothesis that the developing brain operates as an endocrine organ before the establishment of the blood-brain barrier (BBB), in rats up to the first postnatal week. Dopamine (DA) was selected as a marker of the brain endocrine activity. The hypothesis was supported by the observations in rats of: (i) the physiological concentration of DA in peripheral blood of fetuses and neonates, before the BBB establishment, and its drop by prepubertal period, after the BBB development; (ii) a drop of the DA concentration in the brain for 54% and in blood for 74% on the 3rd postnatal day after the intraventricular administration of 50μg of α-methyl-p-tyrosine, an inhibitor of DA synthesis, with no changes in the DA metabolism in peripheral DA-producing organs. Thus, the developing brain is a principal source of circulating DA which is capable of providing an endocrine regulation of peripheral organs and the brain.
KW - Blood-brain barrier
KW - Brain
KW - Development
KW - Dopamine
KW - Neuron
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=80755163599&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2011.07.038
DO - 10.1016/j.mce.2011.07.038
M3 - Article
C2 - 21827827
AN - SCOPUS:80755163599
VL - 348
SP - 78
EP - 86
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1
ER -