Details
| Original language | English |
|---|---|
| Pages (from-to) | 101-111 |
| Number of pages | 11 |
| Journal | Journal of Sensors and Sensor Systems |
| Volume | 7 |
| Issue number | 1 |
| Early online date | 23 Feb 2018 |
| Publication status | Published - 2018 |
Abstract
Split-ring resonators are electrical circuits, which enable highly sensitive readout of split capacity changes via a measurement of the shift in the resonance frequency. Thus, functionalization of the split allows the development of biosensors, where selective molecular binding causes a change in permittivity and therefore a change in split capacity. In this work, we present a novel approach using transmission line theory to describe the dependency between permittivity of the sample and resonance frequency. This theory allows the identification of all relevant parameters of a split-ring resonator and thus a target-oriented optimization process. Hereby all setup optimizations are verified with measurements. Subsequently, the split of a resonator is functionalized with aptamers and the sensor response is investigated. This preliminary experiment shows that introducing the target protein results in a shift in the resonance frequency caused by a permittivity change due to aptamer-mediated protein binding, which allows selective detection of the target protein.
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Instrumentation
- Engineering(all)
- Electrical and Electronic Engineering
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In: Journal of Sensors and Sensor Systems, Vol. 7, No. 1, 2018, p. 101-111.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Design and evaluation of split-ring resonators for aptamer-based biosensors
AU - Reinecke, Tobias
AU - Walter, Johanna Gabriela
AU - Kobelt, Tim
AU - Ahrens, André
AU - Scheper, Thomas
AU - Zimmermann, Stefan
PY - 2018
Y1 - 2018
N2 - Split-ring resonators are electrical circuits, which enable highly sensitive readout of split capacity changes via a measurement of the shift in the resonance frequency. Thus, functionalization of the split allows the development of biosensors, where selective molecular binding causes a change in permittivity and therefore a change in split capacity. In this work, we present a novel approach using transmission line theory to describe the dependency between permittivity of the sample and resonance frequency. This theory allows the identification of all relevant parameters of a split-ring resonator and thus a target-oriented optimization process. Hereby all setup optimizations are verified with measurements. Subsequently, the split of a resonator is functionalized with aptamers and the sensor response is investigated. This preliminary experiment shows that introducing the target protein results in a shift in the resonance frequency caused by a permittivity change due to aptamer-mediated protein binding, which allows selective detection of the target protein.
AB - Split-ring resonators are electrical circuits, which enable highly sensitive readout of split capacity changes via a measurement of the shift in the resonance frequency. Thus, functionalization of the split allows the development of biosensors, where selective molecular binding causes a change in permittivity and therefore a change in split capacity. In this work, we present a novel approach using transmission line theory to describe the dependency between permittivity of the sample and resonance frequency. This theory allows the identification of all relevant parameters of a split-ring resonator and thus a target-oriented optimization process. Hereby all setup optimizations are verified with measurements. Subsequently, the split of a resonator is functionalized with aptamers and the sensor response is investigated. This preliminary experiment shows that introducing the target protein results in a shift in the resonance frequency caused by a permittivity change due to aptamer-mediated protein binding, which allows selective detection of the target protein.
UR - http://www.scopus.com/inward/record.url?scp=85042647838&partnerID=8YFLogxK
U2 - 10.5194/jsss-7-101-2018
DO - 10.5194/jsss-7-101-2018
M3 - Article
AN - SCOPUS:85042647838
VL - 7
SP - 101
EP - 111
JO - Journal of Sensors and Sensor Systems
JF - Journal of Sensors and Sensor Systems
SN - 2194-8771
IS - 1
ER -