Details
| Original language | English |
|---|---|
| Pages (from-to) | S61-S63 |
| Journal | Biomedizinische Technik |
| Volume | 59 |
| Publication status | Published - 1 Oct 2014 |
Abstract
In vitro-hemocompatibility testing is commonly used for parameter studies on e.g. cardiovascular implants or materials for blood-ducting tubing. Two basic working principles for dynamic in vitro-testing have found widespread use: Circuits with roller pump drive and CHANDLER-type apparatus. Both have specific disadvantages. To enhance testing conditions, a new in vitro-test device designed to avoid potentially harmful shear stress and blood-air-contact was constructed and evaluated. Its working principle - an oscillating motion transformed to unidirectional flow by means of an unidirectional restrictor valve - is based on works of WOLF and VAN OEVEREN [1],[2]. Nine different disposable valves from seven manufacturers were evaluated with regard to flow resistance. An adjustable oscillation shaker is used to drive a specimen holder in a housed waterbath. The new system's performance was evaluated for two different valves and porcine whole blood in comparison to a CHANDLER-loop setup. Results show that, at similar wall shear stress, the valves have no adverse effect on background activation and hemolysis, while oxygen saturation is decreased. The new inertial flow device provides a way to avoid blood-air-contact during experiments while allowing simultaneous testing of 18 samples with defined pulsatile flow.
ASJC Scopus subject areas
- Engineering(all)
- Biomedical Engineering
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In: Biomedizinische Technik, Vol. 59, 01.10.2014, p. S61-S63.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Design and evaluation of an inertial flow apparatus for dynamic blood-compatibility testing
AU - Brede, P.
AU - Brede, S.
AU - Kortlepel, R.
AU - Krolitzki, B.
AU - Glasmacher, B.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - In vitro-hemocompatibility testing is commonly used for parameter studies on e.g. cardiovascular implants or materials for blood-ducting tubing. Two basic working principles for dynamic in vitro-testing have found widespread use: Circuits with roller pump drive and CHANDLER-type apparatus. Both have specific disadvantages. To enhance testing conditions, a new in vitro-test device designed to avoid potentially harmful shear stress and blood-air-contact was constructed and evaluated. Its working principle - an oscillating motion transformed to unidirectional flow by means of an unidirectional restrictor valve - is based on works of WOLF and VAN OEVEREN [1],[2]. Nine different disposable valves from seven manufacturers were evaluated with regard to flow resistance. An adjustable oscillation shaker is used to drive a specimen holder in a housed waterbath. The new system's performance was evaluated for two different valves and porcine whole blood in comparison to a CHANDLER-loop setup. Results show that, at similar wall shear stress, the valves have no adverse effect on background activation and hemolysis, while oxygen saturation is decreased. The new inertial flow device provides a way to avoid blood-air-contact during experiments while allowing simultaneous testing of 18 samples with defined pulsatile flow.
AB - In vitro-hemocompatibility testing is commonly used for parameter studies on e.g. cardiovascular implants or materials for blood-ducting tubing. Two basic working principles for dynamic in vitro-testing have found widespread use: Circuits with roller pump drive and CHANDLER-type apparatus. Both have specific disadvantages. To enhance testing conditions, a new in vitro-test device designed to avoid potentially harmful shear stress and blood-air-contact was constructed and evaluated. Its working principle - an oscillating motion transformed to unidirectional flow by means of an unidirectional restrictor valve - is based on works of WOLF and VAN OEVEREN [1],[2]. Nine different disposable valves from seven manufacturers were evaluated with regard to flow resistance. An adjustable oscillation shaker is used to drive a specimen holder in a housed waterbath. The new system's performance was evaluated for two different valves and porcine whole blood in comparison to a CHANDLER-loop setup. Results show that, at similar wall shear stress, the valves have no adverse effect on background activation and hemolysis, while oxygen saturation is decreased. The new inertial flow device provides a way to avoid blood-air-contact during experiments while allowing simultaneous testing of 18 samples with defined pulsatile flow.
UR - http://www.scopus.com/inward/record.url?scp=84908179590&partnerID=8YFLogxK
U2 - 10.1515/bmt-2014-4026
DO - 10.1515/bmt-2014-4026
M3 - Article
AN - SCOPUS:84908179590
VL - 59
SP - S61-S63
JO - Biomedizinische Technik
JF - Biomedizinische Technik
SN - 0013-5585
ER -