Details
| Original language | English |
|---|---|
| Pages (from-to) | 943-959 |
| Number of pages | 17 |
| Journal | Trends in biotechnology |
| Volume | 37 |
| Issue number | 9 |
| Early online date | 16 Apr 2019 |
| Publication status | Published - 9 Sept 2019 |
| Externally published | Yes |
Abstract
‘Ideal’ solvents in biocatalysis have to fulfill a large number of requirements, such as high substrate solubility, high enzyme activity and stability, and positive effects on reaction equilibrium. In the past decades, many enzymatic synthesis routes in water-based and nonaqueous (organic solvents, ionic or supercritical fluids) reaction media have been developed. However, no solvent meets every demand for different reaction types at the same time, and there is still a need for novel solvents suited for different reaction types and applications. Deep eutectic solvents (DESs) have recently been evaluated as solvents in different biocatalytic reactions. They can improve substrate supply, conversion, and stability. The best results were obtained when the DES is formed by the substrates of an enzymatic reaction.
Keywords
- biocatalysis, biotransformations, deep eutectic solvents, natural deep eutectic solvents, reaction medium engineering
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
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In: Trends in biotechnology, Vol. 37, No. 9, 09.09.2019, p. 943-959.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Deep Eutectic Solvents as Efficient Solvents in Biocatalysis
AU - Pätzold, Magdalena
AU - Siebenhaller, Sascha
AU - Kara, Selin
AU - Liese, Andreas
AU - Syldatk, Christoph
AU - Holtmann, Dirk
PY - 2019/9/9
Y1 - 2019/9/9
N2 - ‘Ideal’ solvents in biocatalysis have to fulfill a large number of requirements, such as high substrate solubility, high enzyme activity and stability, and positive effects on reaction equilibrium. In the past decades, many enzymatic synthesis routes in water-based and nonaqueous (organic solvents, ionic or supercritical fluids) reaction media have been developed. However, no solvent meets every demand for different reaction types at the same time, and there is still a need for novel solvents suited for different reaction types and applications. Deep eutectic solvents (DESs) have recently been evaluated as solvents in different biocatalytic reactions. They can improve substrate supply, conversion, and stability. The best results were obtained when the DES is formed by the substrates of an enzymatic reaction.
AB - ‘Ideal’ solvents in biocatalysis have to fulfill a large number of requirements, such as high substrate solubility, high enzyme activity and stability, and positive effects on reaction equilibrium. In the past decades, many enzymatic synthesis routes in water-based and nonaqueous (organic solvents, ionic or supercritical fluids) reaction media have been developed. However, no solvent meets every demand for different reaction types at the same time, and there is still a need for novel solvents suited for different reaction types and applications. Deep eutectic solvents (DESs) have recently been evaluated as solvents in different biocatalytic reactions. They can improve substrate supply, conversion, and stability. The best results were obtained when the DES is formed by the substrates of an enzymatic reaction.
KW - biocatalysis
KW - biotransformations
KW - deep eutectic solvents
KW - natural deep eutectic solvents
KW - reaction medium engineering
UR - http://www.scopus.com/inward/record.url?scp=85064182562&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2019.03.007
DO - 10.1016/j.tibtech.2019.03.007
M3 - Review article
C2 - 31000203
AN - SCOPUS:85064182562
VL - 37
SP - 943
EP - 959
JO - Trends in biotechnology
JF - Trends in biotechnology
SN - 0167-7799
IS - 9
ER -