De novo synthesis of the enantiomers Ins(1,2,3,4)P4 and Ins(1,2,3,6)P4-regiospecificity of their enzymatic dephosphorylation

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Original languageEnglish
Pages (from-to)1057-1061
Number of pages5
JournalTetrahedron Asymmetry
Volume11
Issue number5
Publication statusPublished - 24 Mar 2000
Externally publishedYes

Abstract

The first total synthesis of Ins(1,2,3,4)P4 and Ins(1,2,3,6)P4 is presented. Starting from p-benzoquinone, we took advantage of the C2-symmetry of conduritol-B intermediates. The target compounds were dephosphorylated by several enzymes, and the resulting InsP3 isomers were identified. Some of these enzymatic conversions were found to be preparatively applicable and to allow the synthesis of Ins(1,2,3)P3, Ins(2,3,6)P3 and Ins(1,2,4)P3. Copyright (C) 2000 Elsevier Science Ltd.

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De novo synthesis of the enantiomers Ins(1,2,3,4)P4 and Ins(1,2,3,6)P4-regiospecificity of their enzymatic dephosphorylation. / Plettenburg, O.; Adelt, S.; Vogel, G. et al.
In: Tetrahedron Asymmetry, Vol. 11, No. 5, 24.03.2000, p. 1057-1061.

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abstract = "The first total synthesis of Ins(1,2,3,4)P4 and Ins(1,2,3,6)P4 is presented. Starting from p-benzoquinone, we took advantage of the C2-symmetry of conduritol-B intermediates. The target compounds were dephosphorylated by several enzymes, and the resulting InsP3 isomers were identified. Some of these enzymatic conversions were found to be preparatively applicable and to allow the synthesis of Ins(1,2,3)P3, Ins(2,3,6)P3 and Ins(1,2,4)P3. Copyright (C) 2000 Elsevier Science Ltd.",
author = "O. Plettenburg and S. Adelt and G. Vogel and Altenbach, {H. J.}",
note = "Funding Information: We are grateful to Dr. W. V. Turner for stimulating discussions and critical reading of the manuscript. This work was supported by the Deutsche Forschungsgemeinschaft (grant VO 348/2-2) and the Fonds der Chemischen Industrie.",
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T1 - De novo synthesis of the enantiomers Ins(1,2,3,4)P4 and Ins(1,2,3,6)P4-regiospecificity of their enzymatic dephosphorylation

AU - Plettenburg, O.

AU - Adelt, S.

AU - Vogel, G.

AU - Altenbach, H. J.

N1 - Funding Information: We are grateful to Dr. W. V. Turner for stimulating discussions and critical reading of the manuscript. This work was supported by the Deutsche Forschungsgemeinschaft (grant VO 348/2-2) and the Fonds der Chemischen Industrie.

PY - 2000/3/24

Y1 - 2000/3/24

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