Details
| Translated title of the contribution | The stressful life of Bacillus subtilis |
|---|---|
| Original language | German |
| Pages (from-to) | 150-152 |
| Number of pages | 3 |
| Journal | BioSpektrum |
| Volume | 25 |
| Issue number | 2 |
| Early online date | 26 Mar 2019 |
| Publication status | Published - 1 Apr 2019 |
Abstract
Here we present Bacillus subtilis as a model system to study protein homeostasis and protein quality control in conjunction with the different layers of its stress response systems. We established a new marker to study protein aggregation in vivo. Furthermore, we observed that the transcription factor Spx, which has already been characterized as a central player to activate transcription of redox-chaperones during heat shock and oxidative stress response, was also able to simultaneously inhibit the transcription of translation-related genes as a second response to stress.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
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In: BioSpektrum, Vol. 25, No. 2, 01.04.2019, p. 150-152.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - Das stressige Leben des Bacillus subtilis
AU - Hantke, Ingo
AU - Schäfer, Heinrich
AU - Kramer, Regina
AU - Turgay, Kürşad
N1 - Publisher Copyright: © 2019, Springer-Verlag. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Here we present Bacillus subtilis as a model system to study protein homeostasis and protein quality control in conjunction with the different layers of its stress response systems. We established a new marker to study protein aggregation in vivo. Furthermore, we observed that the transcription factor Spx, which has already been characterized as a central player to activate transcription of redox-chaperones during heat shock and oxidative stress response, was also able to simultaneously inhibit the transcription of translation-related genes as a second response to stress.
AB - Here we present Bacillus subtilis as a model system to study protein homeostasis and protein quality control in conjunction with the different layers of its stress response systems. We established a new marker to study protein aggregation in vivo. Furthermore, we observed that the transcription factor Spx, which has already been characterized as a central player to activate transcription of redox-chaperones during heat shock and oxidative stress response, was also able to simultaneously inhibit the transcription of translation-related genes as a second response to stress.
UR - http://www.scopus.com/inward/record.url?scp=85063568979&partnerID=8YFLogxK
U2 - 10.1007/s12268-019-1023-0
DO - 10.1007/s12268-019-1023-0
M3 - Artikel
AN - SCOPUS:85063568979
VL - 25
SP - 150
EP - 152
JO - BioSpektrum
JF - BioSpektrum
SN - 0947-0867
IS - 2
ER -