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Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases

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Original languageEnglish
Pages (from-to)9-27
Number of pages19
JournalNatural Product Reports
Volume40
Issue number1
Publication statusPublished - 11 May 2022

Abstract

Covering: 1996-2022Investigations over the last 2 decades have begun to reveal how fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in vivo experiments have revealed the interplay of intrinsic and extrinsic selectivity of the component catalytic domains of these systems. Structural biology has begun to provide high resolution structures of hr-PKS that can be used as the basis for their engineering and reprogramming, but progress to-date remains rudimentary. However, significant opportunities exist for translating the current level of understanding into the ability to rationally re-engineer these highly efficient systems for the production of important biologically active compounds through biotechnology.

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Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases. / Cox, Russell J.
In: Natural Product Reports, Vol. 40, No. 1, 11.05.2022, p. 9-27.

Research output: Contribution to journalReview articleResearchpeer review

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