Details
| Original language | English |
|---|---|
| Title of host publication | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
| Subtitle of host publication | Proceedings |
| Pages | 550-551 |
| Number of pages | 2 |
| Volume | 1 |
| Publication status | Published - 18 Jun 2019 |
| Event | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 |
Abstract
Performing high-performance liquid chromatography (HPLC) on a miniaturized scale not only increases the separation efficiency by minimizing all extra-column band broadening effects, but also lowers sample and solvent consumption. In this contribution a new approach in coupling these chip-based analytical devices to ion mobility spectrometry (IMS) is presented. Since an IMS separates formed ions based on their mass, charge, and shape, a highly resolving and sensitive analytical technique is obtained, which generates an additional separation dimension. With first proof-of-concept measurements, the appealing combination of chip-HPLC/ESI-IMS was successfully shown by a 2D-separation of three isobaric antidepressants in less than 15 seconds.
Keywords
- 2D-Separation, Chip-HPLC, IMS, Label-Free Detection
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Chemical Engineering(all)
- Chemical Engineering (miscellaneous)
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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019: Proceedings. Vol. 1 2019. p. 550-551.
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Coupling on-chip separations to ion mobility spectrometry
AU - Hartner, Nora T.
AU - Piendl, Sebastian K.
AU - Raddatz, Christian Robert
AU - Thoben, Christian
AU - Warias, Rico
AU - Zimmermann, Stefan
AU - Belder, Detlev
N1 - Funding Information: This work was financially supported by the Deutsche Forschungsgemeinschaft (DFG) project numbers 396430937, 371350234 and FOR 2177.
PY - 2019/6/18
Y1 - 2019/6/18
N2 - Performing high-performance liquid chromatography (HPLC) on a miniaturized scale not only increases the separation efficiency by minimizing all extra-column band broadening effects, but also lowers sample and solvent consumption. In this contribution a new approach in coupling these chip-based analytical devices to ion mobility spectrometry (IMS) is presented. Since an IMS separates formed ions based on their mass, charge, and shape, a highly resolving and sensitive analytical technique is obtained, which generates an additional separation dimension. With first proof-of-concept measurements, the appealing combination of chip-HPLC/ESI-IMS was successfully shown by a 2D-separation of three isobaric antidepressants in less than 15 seconds.
AB - Performing high-performance liquid chromatography (HPLC) on a miniaturized scale not only increases the separation efficiency by minimizing all extra-column band broadening effects, but also lowers sample and solvent consumption. In this contribution a new approach in coupling these chip-based analytical devices to ion mobility spectrometry (IMS) is presented. Since an IMS separates formed ions based on their mass, charge, and shape, a highly resolving and sensitive analytical technique is obtained, which generates an additional separation dimension. With first proof-of-concept measurements, the appealing combination of chip-HPLC/ESI-IMS was successfully shown by a 2D-separation of three isobaric antidepressants in less than 15 seconds.
KW - 2D-Separation
KW - Chip-HPLC
KW - IMS
KW - Label-Free Detection
UR - http://www.scopus.com/inward/record.url?scp=85094982088&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85094982088
SN - 978-1-7138-1852-6
VL - 1
SP - 550
EP - 551
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -