Details
| Original language | English |
|---|---|
| Pages (from-to) | 7037–7043 |
| Number of pages | 7 |
| Journal | Crystal Growth and Design |
| Volume | 23 |
| Issue number | 10 |
| Early online date | 25 Sept 2023 |
| Publication status | Published - 4 Oct 2023 |
Abstract
Calcium phosphates are widely present in geological and industrial settings and make up the majority of our bone’s inorganic content; however, their formation from solution is not fully understood. The nucleation of calcium phosphate phases was studied using a state-of-the-art titration setup. The effect of varied calcium addition rate was studied at a range of pH values between pH 7 and pH 8; the precipitated crystals were isolated and analyzed. Dicalcium phosphate dihydrate (DCPD) was formed at lower pH and a slow addition rate. Intermediate addition rates yielded a mix of DCPD and poorly crystalline hydroxyapatite (PC-HA). At fast addition rates and above pH 7.5, poorly crystalline hydroxyapatite was precipitated exclusively. The results indicate that counterintuitive kinetic effects play a substantial role in the nucleation of calcium phosphates.
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Materials Science(all)
- General Materials Science
- Physics and Astronomy(all)
- Condensed Matter Physics
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In: Crystal Growth and Design, Vol. 23, No. 10, 04.10.2023, p. 7037–7043.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Counterintuitive Crystallization
T2 - Rate Effects in Calcium Phosphate Nucleation at Near-Physiological pH
AU - McDonogh, David P.
AU - Kirupananthan, Priyanthan
AU - Gebauer, Denis
N1 - Funding Information: We would like to thank the cfMATCH analytics center at the Leibniz University Hannover for support and insight with the TEM measurements.
PY - 2023/10/4
Y1 - 2023/10/4
N2 - Calcium phosphates are widely present in geological and industrial settings and make up the majority of our bone’s inorganic content; however, their formation from solution is not fully understood. The nucleation of calcium phosphate phases was studied using a state-of-the-art titration setup. The effect of varied calcium addition rate was studied at a range of pH values between pH 7 and pH 8; the precipitated crystals were isolated and analyzed. Dicalcium phosphate dihydrate (DCPD) was formed at lower pH and a slow addition rate. Intermediate addition rates yielded a mix of DCPD and poorly crystalline hydroxyapatite (PC-HA). At fast addition rates and above pH 7.5, poorly crystalline hydroxyapatite was precipitated exclusively. The results indicate that counterintuitive kinetic effects play a substantial role in the nucleation of calcium phosphates.
AB - Calcium phosphates are widely present in geological and industrial settings and make up the majority of our bone’s inorganic content; however, their formation from solution is not fully understood. The nucleation of calcium phosphate phases was studied using a state-of-the-art titration setup. The effect of varied calcium addition rate was studied at a range of pH values between pH 7 and pH 8; the precipitated crystals were isolated and analyzed. Dicalcium phosphate dihydrate (DCPD) was formed at lower pH and a slow addition rate. Intermediate addition rates yielded a mix of DCPD and poorly crystalline hydroxyapatite (PC-HA). At fast addition rates and above pH 7.5, poorly crystalline hydroxyapatite was precipitated exclusively. The results indicate that counterintuitive kinetic effects play a substantial role in the nucleation of calcium phosphates.
UR - http://www.scopus.com/inward/record.url?scp=85175154997&partnerID=8YFLogxK
U2 - 10.1021/acs.cgd.3c00851
DO - 10.1021/acs.cgd.3c00851
M3 - Article
AN - SCOPUS:85175154997
VL - 23
SP - 7037
EP - 7043
JO - Crystal Growth and Design
JF - Crystal Growth and Design
SN - 1528-7483
IS - 10
ER -