Details
| Original language | English |
|---|---|
| Pages (from-to) | 82-91 |
| Number of pages | 10 |
| Journal | Macromolecular Symposia |
| Volume | 334 |
| Issue number | 1 |
| Publication status | Published - 18 Dec 2013 |
Abstract
Summary This paper describes and compares the copper-catalyzed and copper-free "click" reaction of N-azido, N-alkynoyl and N-oxanorbornadienyl polysialic acid for the formation of hydrogels and cyclic RGD conjugates. To proof the molecular mechanism of the crosslinking reaction, the crosslinking and conjugation reactions were studied in detail on a molecular level by 1H-NMR spectroscopy and mass spectrometry as well as MS/MS experiments identifying the non-hydrolyzable crosslinks.
Keywords
- click chemistry, hydrogel, polysialic acid, RGD-peptide
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Condensed Matter Physics
- Chemistry(all)
- Organic Chemistry
- Materials Science(all)
- Polymers and Plastics
- Materials Science(all)
- Materials Chemistry
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In: Macromolecular Symposia, Vol. 334, No. 1, 18.12.2013, p. 82-91.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Copper mediated and copper free click decoration of polysialic acid for RGD-modification and hydrogel formation
AU - Su, Yi
AU - Paleček, Jiří
AU - Kirschning, Andreas
AU - Dräger, Gerald
PY - 2013/12/18
Y1 - 2013/12/18
N2 - Summary This paper describes and compares the copper-catalyzed and copper-free "click" reaction of N-azido, N-alkynoyl and N-oxanorbornadienyl polysialic acid for the formation of hydrogels and cyclic RGD conjugates. To proof the molecular mechanism of the crosslinking reaction, the crosslinking and conjugation reactions were studied in detail on a molecular level by 1H-NMR spectroscopy and mass spectrometry as well as MS/MS experiments identifying the non-hydrolyzable crosslinks.
AB - Summary This paper describes and compares the copper-catalyzed and copper-free "click" reaction of N-azido, N-alkynoyl and N-oxanorbornadienyl polysialic acid for the formation of hydrogels and cyclic RGD conjugates. To proof the molecular mechanism of the crosslinking reaction, the crosslinking and conjugation reactions were studied in detail on a molecular level by 1H-NMR spectroscopy and mass spectrometry as well as MS/MS experiments identifying the non-hydrolyzable crosslinks.
KW - click chemistry
KW - hydrogel
KW - polysialic acid
KW - RGD-peptide
UR - http://www.scopus.com/inward/record.url?scp=84890668811&partnerID=8YFLogxK
U2 - 10.1002/masy.201300115
DO - 10.1002/masy.201300115
M3 - Article
AN - SCOPUS:84890668811
VL - 334
SP - 82
EP - 91
JO - Macromolecular Symposia
JF - Macromolecular Symposia
SN - 1022-1360
IS - 1
ER -