Details
| Original language | English |
|---|---|
| Article number | 2310955 |
| Journal | SMALL |
| Volume | 20 |
| Issue number | 36 |
| Publication status | Published - 5 Sept 2024 |
Abstract
DNA origami is a flexible platform for the precise organization of nano-objects, enabling numerous applications from biomedicine to nano-photonics. Its huge potential stems from its high flexibility that allows customized structures to meet specific requirements. The ability to generate diverse final structures from a common base by folding significantly enhances design variety and is regularly occurring in liquid. This study describes a novel approach that combines top-down lithography with bottom-up DNA origami techniques to control folding of the DNA origami with the adsorption on pre-patterned surfaces. Using this approach, tunable plasmonic dimer nano-arrays are fabricated on a silicon surface. This involves employing electron beam lithography to create adsorption sites on the surface and utilizing self-organized adsorption of DNA origami functionalized with two gold nanoparticles (AuNPs). The desired folding of the DNA origami helices can be controlled by the size and shape of the adsorption sites. This approach can for example be used to tune the center-to-center distance of the AuNPs dimers on the origami template. To demonstrate this technique's efficiency, the Raman signal of dye molecules (carboxy tetramethylrhodamine, TAMRA) coated on the AuNPs surface are investigated. These findings highlight the potential of tunable DNA origami-based plasmonic nanostructures for many applications.
Keywords
- AuNPs dimer, distance control, DNA origami, on-surface folding, surface enhanced Raman spectroscopy
ASJC Scopus subject areas
- Engineering(all)
- Engineering (miscellaneous)
- Chemistry(all)
- General Chemistry
- Materials Science(all)
- General Materials Science
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Materials Science(all)
- Biomaterials
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In: SMALL, Vol. 20, No. 36, 2310955, 05.09.2024.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding
AU - Liu, Zhe
AU - Wang, Zunhao
AU - Guckel, Jannik
AU - Akbarian, Ziba
AU - Seifert, Tim j.
AU - Park, Daesung
AU - Schlickum, Uta
AU - Stosch, Rainer
AU - Etzkorn, Markus
N1 - Publisher Copyright: © 2024 The Authors. Small published by Wiley-VCH GmbH.
PY - 2024/9/5
Y1 - 2024/9/5
N2 - DNA origami is a flexible platform for the precise organization of nano-objects, enabling numerous applications from biomedicine to nano-photonics. Its huge potential stems from its high flexibility that allows customized structures to meet specific requirements. The ability to generate diverse final structures from a common base by folding significantly enhances design variety and is regularly occurring in liquid. This study describes a novel approach that combines top-down lithography with bottom-up DNA origami techniques to control folding of the DNA origami with the adsorption on pre-patterned surfaces. Using this approach, tunable plasmonic dimer nano-arrays are fabricated on a silicon surface. This involves employing electron beam lithography to create adsorption sites on the surface and utilizing self-organized adsorption of DNA origami functionalized with two gold nanoparticles (AuNPs). The desired folding of the DNA origami helices can be controlled by the size and shape of the adsorption sites. This approach can for example be used to tune the center-to-center distance of the AuNPs dimers on the origami template. To demonstrate this technique's efficiency, the Raman signal of dye molecules (carboxy tetramethylrhodamine, TAMRA) coated on the AuNPs surface are investigated. These findings highlight the potential of tunable DNA origami-based plasmonic nanostructures for many applications.
AB - DNA origami is a flexible platform for the precise organization of nano-objects, enabling numerous applications from biomedicine to nano-photonics. Its huge potential stems from its high flexibility that allows customized structures to meet specific requirements. The ability to generate diverse final structures from a common base by folding significantly enhances design variety and is regularly occurring in liquid. This study describes a novel approach that combines top-down lithography with bottom-up DNA origami techniques to control folding of the DNA origami with the adsorption on pre-patterned surfaces. Using this approach, tunable plasmonic dimer nano-arrays are fabricated on a silicon surface. This involves employing electron beam lithography to create adsorption sites on the surface and utilizing self-organized adsorption of DNA origami functionalized with two gold nanoparticles (AuNPs). The desired folding of the DNA origami helices can be controlled by the size and shape of the adsorption sites. This approach can for example be used to tune the center-to-center distance of the AuNPs dimers on the origami template. To demonstrate this technique's efficiency, the Raman signal of dye molecules (carboxy tetramethylrhodamine, TAMRA) coated on the AuNPs surface are investigated. These findings highlight the potential of tunable DNA origami-based plasmonic nanostructures for many applications.
KW - AuNPs dimer
KW - distance control
KW - DNA origami
KW - on-surface folding
KW - surface enhanced Raman spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85190536183&partnerID=8YFLogxK
U2 - 10.1002/smll.202310955
DO - 10.1002/smll.202310955
M3 - Article
VL - 20
JO - SMALL
JF - SMALL
SN - 1613-6810
IS - 36
M1 - 2310955
ER -