Details
| Original language | English |
|---|---|
| Article number | 128372 |
| Journal | Sensors and Actuators, B: Chemical |
| Volume | 320 |
| Early online date | 29 May 2020 |
| Publication status | Published - 1 Oct 2020 |
Abstract
A frequent complication of critically ill patients in intensive care units suffering from acute kidney injury is a severe dysnatremia requiring a continuous renal replacement therapy. For such patients, an individual dialysis treatment with an individual composition of the dialysate to limit the rate of serum sodium normalization has a positive effect on patients’ recovery. However, a precise control of the serum sodium concentration change requires continuous sodium monitoring. Drawing blood samples and analyzing such samples with a blood gas analyzer gives the serum sodium concentration with an absolute accuracy of about 2 mmol/L and a precision of 0.6 mmol/L. Nevertheless, blood gas analyzers do not allow for continuous serum sodium monitoring. Therefore, we present a new sensing concept based on a differential transformer consisting of printed circuit board coils for contactless and noninvasive monitoring of the serum sodium concentration during continuous renal replacement therapy to enable an individual sodium management. This sensing concept covers a linear operating range from 100 mmol/L to 170 mmol/L, comparable to commercially available blood gas analyzers. In a preclinical investigation using reconfigured human packed red blood cells as test medium, we could continuously measure the serum sodium concentration with an absolute accuracy of 4 mmol/L compared to the reference and a precision of 0.3 mmol/L. Moreover, we have established an analytical expression to optimize the differential transformer coils, resulting in a high sensitivity of 192 mV/mol/L.
Keywords
- Contactless sodium monitoring, Differential transformer, Individualized dialysis treatment, Measuring blood parameters
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Instrumentation
- Physics and Astronomy(all)
- Condensed Matter Physics
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Metals and Alloys
- Engineering(all)
- Electrical and Electronic Engineering
- Materials Science(all)
- Materials Chemistry
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In: Sensors and Actuators, B: Chemical, Vol. 320, 128372, 01.10.2020.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Contactless and continuous sodium concentration monitoring during continuous renal replacement therapy
AU - Berger, Marc
AU - Zygmanowski, Anne
AU - Sellering, Flora
AU - Röhrich, Hannes
AU - Perl, Thorsten
AU - Mansour, Hussam
AU - Zimmermann, Stefan
N1 - Funding Information: Supported by the German Federal Ministry of Education and Research (BMBF) under the grant 13GW0085B .
PY - 2020/10/1
Y1 - 2020/10/1
N2 - A frequent complication of critically ill patients in intensive care units suffering from acute kidney injury is a severe dysnatremia requiring a continuous renal replacement therapy. For such patients, an individual dialysis treatment with an individual composition of the dialysate to limit the rate of serum sodium normalization has a positive effect on patients’ recovery. However, a precise control of the serum sodium concentration change requires continuous sodium monitoring. Drawing blood samples and analyzing such samples with a blood gas analyzer gives the serum sodium concentration with an absolute accuracy of about 2 mmol/L and a precision of 0.6 mmol/L. Nevertheless, blood gas analyzers do not allow for continuous serum sodium monitoring. Therefore, we present a new sensing concept based on a differential transformer consisting of printed circuit board coils for contactless and noninvasive monitoring of the serum sodium concentration during continuous renal replacement therapy to enable an individual sodium management. This sensing concept covers a linear operating range from 100 mmol/L to 170 mmol/L, comparable to commercially available blood gas analyzers. In a preclinical investigation using reconfigured human packed red blood cells as test medium, we could continuously measure the serum sodium concentration with an absolute accuracy of 4 mmol/L compared to the reference and a precision of 0.3 mmol/L. Moreover, we have established an analytical expression to optimize the differential transformer coils, resulting in a high sensitivity of 192 mV/mol/L.
AB - A frequent complication of critically ill patients in intensive care units suffering from acute kidney injury is a severe dysnatremia requiring a continuous renal replacement therapy. For such patients, an individual dialysis treatment with an individual composition of the dialysate to limit the rate of serum sodium normalization has a positive effect on patients’ recovery. However, a precise control of the serum sodium concentration change requires continuous sodium monitoring. Drawing blood samples and analyzing such samples with a blood gas analyzer gives the serum sodium concentration with an absolute accuracy of about 2 mmol/L and a precision of 0.6 mmol/L. Nevertheless, blood gas analyzers do not allow for continuous serum sodium monitoring. Therefore, we present a new sensing concept based on a differential transformer consisting of printed circuit board coils for contactless and noninvasive monitoring of the serum sodium concentration during continuous renal replacement therapy to enable an individual sodium management. This sensing concept covers a linear operating range from 100 mmol/L to 170 mmol/L, comparable to commercially available blood gas analyzers. In a preclinical investigation using reconfigured human packed red blood cells as test medium, we could continuously measure the serum sodium concentration with an absolute accuracy of 4 mmol/L compared to the reference and a precision of 0.3 mmol/L. Moreover, we have established an analytical expression to optimize the differential transformer coils, resulting in a high sensitivity of 192 mV/mol/L.
KW - Contactless sodium monitoring
KW - Differential transformer
KW - Individualized dialysis treatment
KW - Measuring blood parameters
UR - http://www.scopus.com/inward/record.url?scp=85086362097&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2020.128372
DO - 10.1016/j.snb.2020.128372
M3 - Article
AN - SCOPUS:85086362097
VL - 320
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
M1 - 128372
ER -