Details
| Original language | English |
|---|---|
| Pages (from-to) | 281-294 |
| Number of pages | 14 |
| Journal | Journal of Biomaterials Applications |
| Volume | 33 |
| Issue number | 2 |
| Publication status | Published - 13 Jul 2018 |
Abstract
Biodegradable materials play a crucial role in both material and medical sciences and are frequently used as a primary commodity for implants generation. Due to their material inherent properties, they are supposed to be entirely resorbed by the patients' body after fulfilling their task as a scaffold. This makes a second intervention (e.g. for implant removal) redundant and significantly enhances a patient’s post-operative life quality. At the moment, materials for resorbable and biodegradable implants (e.g. polylactic acid or poly-caprolactone polymers) are still intensively studied. They are able to provide mandatory demands such as mechanical strength and attributes needed for high-quality implants. Implants, however, not only need to be made of adequate material, but must also to be personalized in order to meet the customers’ needs. Combining three dimensional-printing and high-resolution imaging technologies a new age of implant production comes into sight. Three dimensional images (e.g. magnetic resonance imaging or computed tomography) of tissue defects can be utilized as digital blueprints for personalized implants. Modern additive manufacturing devices are able to use a variety of materials to fabricate custom parts within short periods of time. The combination of high-quality resorbable materials and personalized three dimensional-printing for the custom application will provide the patients with the best suitable and sustainable implants. In this study, we evaluated and compared four resorbable and three dimensional printable materials for their in vitro biocompatibility, in vitro rate of degradation, cell adherence and behavior on these materials as well as support of osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells. The tests were conducted with model constructs of 1 cm2 surface area fabricated with fused deposition modeling three dimensional-printing technology.
Keywords
- Additive manufacturing, in vitro biocompatibility, in vitro degradation, mesenchymal stem cells, non-permanent implants, osteogenic differentiation, RESOMERS®, resorbable polymers
ASJC Scopus subject areas
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
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In: Journal of Biomaterials Applications, Vol. 33, No. 2, 13.07.2018, p. 281-294.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Comparison of different three dimensional-printed resorbable materials
T2 - In vitro biocompatibility, In vitro degradation rate, and cell differentiation support
AU - Raddatz, Lukas
AU - Kirsch, Marline
AU - Geier, Dominik
AU - Schaeske, Jörn
AU - Acreman, Kevin
AU - Gentsch, Rafael
AU - Jones, Scott
AU - Karau, Andreas
AU - Washington, Tommy
AU - Stiesch, Meike
AU - Becker, Thomas
AU - Beutel, Sascha
AU - Scheper, Thomas
AU - Lavrentieva, Antonina
N1 - Funding information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was also supported by the “Biofabrication for NIFE” cluster funded by the State of Lower Saxony ministry of Science and Culture and the Volkswagen Stiftung.
PY - 2018/7/13
Y1 - 2018/7/13
N2 - Biodegradable materials play a crucial role in both material and medical sciences and are frequently used as a primary commodity for implants generation. Due to their material inherent properties, they are supposed to be entirely resorbed by the patients' body after fulfilling their task as a scaffold. This makes a second intervention (e.g. for implant removal) redundant and significantly enhances a patient’s post-operative life quality. At the moment, materials for resorbable and biodegradable implants (e.g. polylactic acid or poly-caprolactone polymers) are still intensively studied. They are able to provide mandatory demands such as mechanical strength and attributes needed for high-quality implants. Implants, however, not only need to be made of adequate material, but must also to be personalized in order to meet the customers’ needs. Combining three dimensional-printing and high-resolution imaging technologies a new age of implant production comes into sight. Three dimensional images (e.g. magnetic resonance imaging or computed tomography) of tissue defects can be utilized as digital blueprints for personalized implants. Modern additive manufacturing devices are able to use a variety of materials to fabricate custom parts within short periods of time. The combination of high-quality resorbable materials and personalized three dimensional-printing for the custom application will provide the patients with the best suitable and sustainable implants. In this study, we evaluated and compared four resorbable and three dimensional printable materials for their in vitro biocompatibility, in vitro rate of degradation, cell adherence and behavior on these materials as well as support of osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells. The tests were conducted with model constructs of 1 cm2 surface area fabricated with fused deposition modeling three dimensional-printing technology.
AB - Biodegradable materials play a crucial role in both material and medical sciences and are frequently used as a primary commodity for implants generation. Due to their material inherent properties, they are supposed to be entirely resorbed by the patients' body after fulfilling their task as a scaffold. This makes a second intervention (e.g. for implant removal) redundant and significantly enhances a patient’s post-operative life quality. At the moment, materials for resorbable and biodegradable implants (e.g. polylactic acid or poly-caprolactone polymers) are still intensively studied. They are able to provide mandatory demands such as mechanical strength and attributes needed for high-quality implants. Implants, however, not only need to be made of adequate material, but must also to be personalized in order to meet the customers’ needs. Combining three dimensional-printing and high-resolution imaging technologies a new age of implant production comes into sight. Three dimensional images (e.g. magnetic resonance imaging or computed tomography) of tissue defects can be utilized as digital blueprints for personalized implants. Modern additive manufacturing devices are able to use a variety of materials to fabricate custom parts within short periods of time. The combination of high-quality resorbable materials and personalized three dimensional-printing for the custom application will provide the patients with the best suitable and sustainable implants. In this study, we evaluated and compared four resorbable and three dimensional printable materials for their in vitro biocompatibility, in vitro rate of degradation, cell adherence and behavior on these materials as well as support of osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells. The tests were conducted with model constructs of 1 cm2 surface area fabricated with fused deposition modeling three dimensional-printing technology.
KW - Additive manufacturing
KW - in vitro biocompatibility
KW - in vitro degradation
KW - mesenchymal stem cells
KW - non-permanent implants
KW - osteogenic differentiation
KW - RESOMERS®
KW - resorbable polymers
UR - http://www.scopus.com/inward/record.url?scp=85049871353&partnerID=8YFLogxK
U2 - 10.1177/0885328218787219
DO - 10.1177/0885328218787219
M3 - Article
C2 - 30004265
AN - SCOPUS:85049871353
VL - 33
SP - 281
EP - 294
JO - Journal of Biomaterials Applications
JF - Journal of Biomaterials Applications
SN - 0885-3282
IS - 2
ER -