Details
| Original language | English |
|---|---|
| Journal | Natural product reports |
| Early online date | 15 Apr 2024 |
| Publication status | E-pub ahead of print - 15 Apr 2024 |
Abstract
Covering the period 1965-2024 Total synthesis has been defined as the art and science of making the molecules of living Nature in the laboratory, and by extension, their analogues. At the extremes, specialised metabolites can be created by total chemical synthesis or by total biosynthesis. In this review we explore the advantages and disadvantages of these two approaches using quantitative methodology that combines measures of molecular complexity, molecular weight and fraction of sp3 centres for bioactive fungal metabolites. Total biosynthesis usually involves fewer chemical steps and those steps move more directly to the target than comparable total chemical synthesis. However, total biosynthesis currently lacks the flexibility of chemical synthesis and the ability to easily diversify synthetic routes.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural product reports, 15.04.2024.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites
AU - Tian, Dong Song
AU - Zhang, Xiao
AU - Cox, Russell J.
PY - 2024/4/15
Y1 - 2024/4/15
N2 - Covering the period 1965-2024 Total synthesis has been defined as the art and science of making the molecules of living Nature in the laboratory, and by extension, their analogues. At the extremes, specialised metabolites can be created by total chemical synthesis or by total biosynthesis. In this review we explore the advantages and disadvantages of these two approaches using quantitative methodology that combines measures of molecular complexity, molecular weight and fraction of sp3 centres for bioactive fungal metabolites. Total biosynthesis usually involves fewer chemical steps and those steps move more directly to the target than comparable total chemical synthesis. However, total biosynthesis currently lacks the flexibility of chemical synthesis and the ability to easily diversify synthetic routes.
AB - Covering the period 1965-2024 Total synthesis has been defined as the art and science of making the molecules of living Nature in the laboratory, and by extension, their analogues. At the extremes, specialised metabolites can be created by total chemical synthesis or by total biosynthesis. In this review we explore the advantages and disadvantages of these two approaches using quantitative methodology that combines measures of molecular complexity, molecular weight and fraction of sp3 centres for bioactive fungal metabolites. Total biosynthesis usually involves fewer chemical steps and those steps move more directly to the target than comparable total chemical synthesis. However, total biosynthesis currently lacks the flexibility of chemical synthesis and the ability to easily diversify synthetic routes.
UR - http://www.scopus.com/inward/record.url?scp=85201429353&partnerID=8YFLogxK
U2 - 10.1039/d4np00015c
DO - 10.1039/d4np00015c
M3 - Review article
AN - SCOPUS:85201429353
JO - Natural product reports
JF - Natural product reports
SN - 0265-0568
ER -