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Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites

Research output: Contribution to journalReview articleResearchpeer review

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  • Southwest University
  • Guangzhou University of Traditional Chinese Medicine

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Original languageEnglish
JournalNatural product reports
Early online date15 Apr 2024
Publication statusE-pub ahead of print - 15 Apr 2024

Abstract

Covering the period 1965-2024 Total synthesis has been defined as the art and science of making the molecules of living Nature in the laboratory, and by extension, their analogues. At the extremes, specialised metabolites can be created by total chemical synthesis or by total biosynthesis. In this review we explore the advantages and disadvantages of these two approaches using quantitative methodology that combines measures of molecular complexity, molecular weight and fraction of sp3 centres for bioactive fungal metabolites. Total biosynthesis usually involves fewer chemical steps and those steps move more directly to the target than comparable total chemical synthesis. However, total biosynthesis currently lacks the flexibility of chemical synthesis and the ability to easily diversify synthetic routes.

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Cite this

Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites. / Tian, Dong Song; Zhang, Xiao; Cox, Russell J.
In: Natural product reports, 15.04.2024.

Research output: Contribution to journalReview articleResearchpeer review

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