Details
| Original language | English |
|---|---|
| Pages (from-to) | 2667-2672 |
| Number of pages | 6 |
| Journal | Journal of orthopaedic research |
| Volume | 35 |
| Issue number | 12 |
| Publication status | Published - 7 Apr 2017 |
Abstract
Bone density measurements using computed tomography (CT) instead of dual-energy X-ray absorptiometry (DEXA) are currently of great interest in human and veterinary medical research as it would be beneficial to use CT scans obtained for other indications also for determining bone density. For Hounsfield units (HU) measured with CT in specific regions of interests (ROIs) in one or several slice/s a correlation with bone mineral density (BMD) measured by DEXA in humans and dogs of between 0.44 and 0.77 is reported in the literature. In the present study, instead certain volumes of interest (VOIs) obtained by CT scan and the corresponding HU to the respective VOIs were compared with the bone mineral density of the corresponding areas measured by DEXA. The aim of the study was to investigate whether this procedure gives more accurate information about bone density of the bones as three-dimensional objects of the respective patient. Correlation between measured HU in the respective VOI and BMD measured with DEXA in the corresponding ROI showed a very good correlation of 0.93. Linear regression with R2 = 0.85 (p = 0.0262) was calculated. Except for VOI5, similar distribution of values and significant differences (p < 0.0001–0.0087) between ROIs/VOIs were detected. Determining HU for assessing bone mineral density in a certain volume provides more accurate results than those previously reported from two-dimensional (2D) CT measurements.
Keywords
- bone mineral density, canine femur, computed tomography, DEXA, volume of interest
ASJC Scopus subject areas
- Medicine(all)
- Orthopedics and Sports Medicine
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In: Journal of orthopaedic research, Vol. 35, No. 12, 07.04.2017, p. 2667-2672.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Comparative Investigation of Bone Mineral Density Using CT and DEXA in a Canine Femoral Model
AU - Lucas, Karin
AU - Behrens, Bernd Arno
AU - Nolte, Ingo
AU - Galindo-Zamora, Vladimir
AU - Betancur, Stefanie
AU - Almohallami, Amer
AU - Bouguecha, Anas
AU - Mostafa, Ayman
AU - Lerch, Matthias
AU - Stukenborg-Colsman, Christina
AU - Wefstaedt, Patrick
N1 - Funding information: This study was performed in association with the subproject D6 of the Collaborative Research Center 599 “Sustainable degradable and permanent implants out of metallic and ceramic materials.” The authors wish to thank the German Research Foundation (DFG) for providing financial support.
PY - 2017/4/7
Y1 - 2017/4/7
N2 - Bone density measurements using computed tomography (CT) instead of dual-energy X-ray absorptiometry (DEXA) are currently of great interest in human and veterinary medical research as it would be beneficial to use CT scans obtained for other indications also for determining bone density. For Hounsfield units (HU) measured with CT in specific regions of interests (ROIs) in one or several slice/s a correlation with bone mineral density (BMD) measured by DEXA in humans and dogs of between 0.44 and 0.77 is reported in the literature. In the present study, instead certain volumes of interest (VOIs) obtained by CT scan and the corresponding HU to the respective VOIs were compared with the bone mineral density of the corresponding areas measured by DEXA. The aim of the study was to investigate whether this procedure gives more accurate information about bone density of the bones as three-dimensional objects of the respective patient. Correlation between measured HU in the respective VOI and BMD measured with DEXA in the corresponding ROI showed a very good correlation of 0.93. Linear regression with R2 = 0.85 (p = 0.0262) was calculated. Except for VOI5, similar distribution of values and significant differences (p < 0.0001–0.0087) between ROIs/VOIs were detected. Determining HU for assessing bone mineral density in a certain volume provides more accurate results than those previously reported from two-dimensional (2D) CT measurements.
AB - Bone density measurements using computed tomography (CT) instead of dual-energy X-ray absorptiometry (DEXA) are currently of great interest in human and veterinary medical research as it would be beneficial to use CT scans obtained for other indications also for determining bone density. For Hounsfield units (HU) measured with CT in specific regions of interests (ROIs) in one or several slice/s a correlation with bone mineral density (BMD) measured by DEXA in humans and dogs of between 0.44 and 0.77 is reported in the literature. In the present study, instead certain volumes of interest (VOIs) obtained by CT scan and the corresponding HU to the respective VOIs were compared with the bone mineral density of the corresponding areas measured by DEXA. The aim of the study was to investigate whether this procedure gives more accurate information about bone density of the bones as three-dimensional objects of the respective patient. Correlation between measured HU in the respective VOI and BMD measured with DEXA in the corresponding ROI showed a very good correlation of 0.93. Linear regression with R2 = 0.85 (p = 0.0262) was calculated. Except for VOI5, similar distribution of values and significant differences (p < 0.0001–0.0087) between ROIs/VOIs were detected. Determining HU for assessing bone mineral density in a certain volume provides more accurate results than those previously reported from two-dimensional (2D) CT measurements.
KW - bone mineral density
KW - canine femur
KW - computed tomography
KW - DEXA
KW - volume of interest
UR - http://www.scopus.com/inward/record.url?scp=85018273098&partnerID=8YFLogxK
U2 - 10.1002/jor.23574
DO - 10.1002/jor.23574
M3 - Article
C2 - 28387962
AN - SCOPUS:85018273098
VL - 35
SP - 2667
EP - 2672
JO - Journal of orthopaedic research
JF - Journal of orthopaedic research
SN - 0736-0266
IS - 12
ER -