Details
| Original language | English |
|---|---|
| Pages (from-to) | 230-256 |
| Number of pages | 27 |
| Journal | Natural product reports |
| Volume | 35 |
| Issue number | 3 |
| Publication status | Published - 1 Mar 2018 |
Abstract
Covering: 1893 to 2017 Harold Raistrick was involved in the discovery of many of the most important classes of fungal metabolites during the 20th century. This review focusses on how these discoveries led to developments in isotopic labelling, biomimetic chemistry and the discovery, analysis and exploitation of biosynthetic gene clusters for major classes of fungal metabolites including: alternariol; geodin and metabolites of the emodin pathway; maleidrides; citrinin and the azaphilones; dehydrocurvularin; mycophenolic acid; and the tropolones. Key recent advances in the molecular understanding of these important pathways, including the discovery of biosynthetic gene clusters, the investigation of the molecular and chemical aspects of key biosynthetic steps, and the reengineering of key components of the pathways are reviewed and compared. Finally, discussion of key relationships between metabolites and pathways and the most important recent advances and opportunities for future research directions are given.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural product reports, Vol. 35, No. 3, 01.03.2018, p. 230-256.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Classic fungal natural products in the genomic age: the molecular legacy of Harold Raistrick
AU - Schor, Raissa
AU - Cox, Russell
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Covering: 1893 to 2017 Harold Raistrick was involved in the discovery of many of the most important classes of fungal metabolites during the 20th century. This review focusses on how these discoveries led to developments in isotopic labelling, biomimetic chemistry and the discovery, analysis and exploitation of biosynthetic gene clusters for major classes of fungal metabolites including: alternariol; geodin and metabolites of the emodin pathway; maleidrides; citrinin and the azaphilones; dehydrocurvularin; mycophenolic acid; and the tropolones. Key recent advances in the molecular understanding of these important pathways, including the discovery of biosynthetic gene clusters, the investigation of the molecular and chemical aspects of key biosynthetic steps, and the reengineering of key components of the pathways are reviewed and compared. Finally, discussion of key relationships between metabolites and pathways and the most important recent advances and opportunities for future research directions are given.
AB - Covering: 1893 to 2017 Harold Raistrick was involved in the discovery of many of the most important classes of fungal metabolites during the 20th century. This review focusses on how these discoveries led to developments in isotopic labelling, biomimetic chemistry and the discovery, analysis and exploitation of biosynthetic gene clusters for major classes of fungal metabolites including: alternariol; geodin and metabolites of the emodin pathway; maleidrides; citrinin and the azaphilones; dehydrocurvularin; mycophenolic acid; and the tropolones. Key recent advances in the molecular understanding of these important pathways, including the discovery of biosynthetic gene clusters, the investigation of the molecular and chemical aspects of key biosynthetic steps, and the reengineering of key components of the pathways are reviewed and compared. Finally, discussion of key relationships between metabolites and pathways and the most important recent advances and opportunities for future research directions are given.
UR - http://www.scopus.com/inward/record.url?scp=85044268803&partnerID=8YFLogxK
U2 - 10.1039/c8np00021b
DO - 10.1039/c8np00021b
M3 - Article
C2 - 29537034
AN - SCOPUS:85044268803
VL - 35
SP - 230
EP - 256
JO - Natural product reports
JF - Natural product reports
SN - 0265-0568
IS - 3
ER -