Details
| Translated title of the contribution | Chronic allograft dysfunction. Causes and possibilities for minimizing progression |
|---|---|
| Original language | German |
| Pages (from-to) | 241-254 |
| Number of pages | 14 |
| Journal | Nephrologe |
| Volume | 1 |
| Issue number | 4 |
| Publication status | Published - Nov 2006 |
| Externally published | Yes |
Abstract
Chronic transplant dysfunction is a complex dynamic pathogenic process. Clinically, a decrease in glomerular filtration rate (GFR) becomes apparent leading to chronic renal insufficiency and dialysis or death from cardiovascular events. Chronic transplant dysfunction can develop into a chronic alIograft nephropathy (CAN) as a specific entity with dynamic progression. CAN includes a collection of immunologic and non-immunologic factors, rejection, ischemia time, donor and recipient characteristics and toxicity of calcineurin inhibitors. Despite improvements in immunosuppression, the long-range prognosis of renal allografts has not improved. Whether modern immunosuppressive concepts with reduction or avoidance of calcineurin inhibitors and a therapy based on antimetabolites, such as mycophenolate or mTOR-inhibitors could lead to a prolongation of transplant survival, remains to be seen.
ASJC Scopus subject areas
- Medicine(all)
- Nephrology
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In: Nephrologe, Vol. 1, No. 4, 11.2006, p. 241-254.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Chronische Transplantatdysfunktion
T2 - Ursachen und Möglichkeiten zur Beeinflussung der Progression
AU - Blume, Cornelia
AU - Kurschat, C. E.
AU - Helmchen, Udo
AU - Grabensee, B.
PY - 2006/11
Y1 - 2006/11
N2 - Chronic transplant dysfunction is a complex dynamic pathogenic process. Clinically, a decrease in glomerular filtration rate (GFR) becomes apparent leading to chronic renal insufficiency and dialysis or death from cardiovascular events. Chronic transplant dysfunction can develop into a chronic alIograft nephropathy (CAN) as a specific entity with dynamic progression. CAN includes a collection of immunologic and non-immunologic factors, rejection, ischemia time, donor and recipient characteristics and toxicity of calcineurin inhibitors. Despite improvements in immunosuppression, the long-range prognosis of renal allografts has not improved. Whether modern immunosuppressive concepts with reduction or avoidance of calcineurin inhibitors and a therapy based on antimetabolites, such as mycophenolate or mTOR-inhibitors could lead to a prolongation of transplant survival, remains to be seen.
AB - Chronic transplant dysfunction is a complex dynamic pathogenic process. Clinically, a decrease in glomerular filtration rate (GFR) becomes apparent leading to chronic renal insufficiency and dialysis or death from cardiovascular events. Chronic transplant dysfunction can develop into a chronic alIograft nephropathy (CAN) as a specific entity with dynamic progression. CAN includes a collection of immunologic and non-immunologic factors, rejection, ischemia time, donor and recipient characteristics and toxicity of calcineurin inhibitors. Despite improvements in immunosuppression, the long-range prognosis of renal allografts has not improved. Whether modern immunosuppressive concepts with reduction or avoidance of calcineurin inhibitors and a therapy based on antimetabolites, such as mycophenolate or mTOR-inhibitors could lead to a prolongation of transplant survival, remains to be seen.
KW - Chronic allograft nephropathy (CAN)
KW - Chronic transplant dysfunction
KW - Immunosuppression
KW - Nephrotoxicity
KW - Renal transplantation
UR - http://www.scopus.com/inward/record.url?scp=33750963467&partnerID=8YFLogxK
U2 - 10.1007/s11560-006-0045-z
DO - 10.1007/s11560-006-0045-z
M3 - Artikel
AN - SCOPUS:33750963467
VL - 1
SP - 241
EP - 254
JO - Nephrologe
JF - Nephrologe
SN - 1862-040X
IS - 4
ER -