Details
| Translated title of the contribution | Choline: Good for your liver, but bad for your heart? |
|---|---|
| Original language | German |
| Pages (from-to) | 57-67 |
| Number of pages | 11 |
| Journal | Medizinische Monatsschrift fur Pharmazeuten |
| Volume | 43 |
| Issue number | 2 |
| Publication status | Published - 2020 |
Abstract
Choline is an ubiquitous amino alcohol. In food, about 95 % of choline is found as phosphatidylcholine (syn. lecithin). Unlike breast milk, choline is found naturally in only a few foods, such as chicken eggs and liver. The absorption of choline takes place in a multi-stage process and in case of lipid-soluble choline esters it is closely linked to the absorption of the neutral fats. In the target tissues choline is stored either in form of membrane-bound phospholipids or as intracellular phosphatidylcholine or glycerophosphocholine. Choline-containing biomolecules fulfill different physiological functions in the human body. The principal function of choline is to maintain the structural integrity of biomembranes (synthesis of phosphatidylcholine), neurotransmission (formation of acetylcholine) and lipoprotein metabolism (synthesis of VLDL). In the liver choline can be synthesized from phosphatidyl - ethalonamine, which is converted to phosphatidylcholine by triple methylation. However, endogene biosynthesis of choline does not ensure sufficient supply. Most vulnerable groups are menopausal women as well as people with certain polymorphisms in the metabolism of methionine, folate and choline. Hence, choline is a vitamin-like essential nutrient for humans. Therefore, a recommended adequate intake of choline was set at 400 to 425 mg per day for women and 400 to 550 mg per day for men. Choline is usually well tolerated even at an intake of several grams per day. The tolerable upper intake level (UL) for adults is 3.5 g of choline per day.
ASJC Scopus subject areas
- Medicine(all)
- Pharmacology (medical)
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In: Medizinische Monatsschrift fur Pharmazeuten, Vol. 43, No. 2, 2020, p. 57-67.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - Cholin – Gut für die Leber, aber schlecht für das Herz?
AU - Ströhle, A.
AU - Hahn, A.
PY - 2020
Y1 - 2020
N2 - Choline is an ubiquitous amino alcohol. In food, about 95 % of choline is found as phosphatidylcholine (syn. lecithin). Unlike breast milk, choline is found naturally in only a few foods, such as chicken eggs and liver. The absorption of choline takes place in a multi-stage process and in case of lipid-soluble choline esters it is closely linked to the absorption of the neutral fats. In the target tissues choline is stored either in form of membrane-bound phospholipids or as intracellular phosphatidylcholine or glycerophosphocholine. Choline-containing biomolecules fulfill different physiological functions in the human body. The principal function of choline is to maintain the structural integrity of biomembranes (synthesis of phosphatidylcholine), neurotransmission (formation of acetylcholine) and lipoprotein metabolism (synthesis of VLDL). In the liver choline can be synthesized from phosphatidyl - ethalonamine, which is converted to phosphatidylcholine by triple methylation. However, endogene biosynthesis of choline does not ensure sufficient supply. Most vulnerable groups are menopausal women as well as people with certain polymorphisms in the metabolism of methionine, folate and choline. Hence, choline is a vitamin-like essential nutrient for humans. Therefore, a recommended adequate intake of choline was set at 400 to 425 mg per day for women and 400 to 550 mg per day for men. Choline is usually well tolerated even at an intake of several grams per day. The tolerable upper intake level (UL) for adults is 3.5 g of choline per day.
AB - Choline is an ubiquitous amino alcohol. In food, about 95 % of choline is found as phosphatidylcholine (syn. lecithin). Unlike breast milk, choline is found naturally in only a few foods, such as chicken eggs and liver. The absorption of choline takes place in a multi-stage process and in case of lipid-soluble choline esters it is closely linked to the absorption of the neutral fats. In the target tissues choline is stored either in form of membrane-bound phospholipids or as intracellular phosphatidylcholine or glycerophosphocholine. Choline-containing biomolecules fulfill different physiological functions in the human body. The principal function of choline is to maintain the structural integrity of biomembranes (synthesis of phosphatidylcholine), neurotransmission (formation of acetylcholine) and lipoprotein metabolism (synthesis of VLDL). In the liver choline can be synthesized from phosphatidyl - ethalonamine, which is converted to phosphatidylcholine by triple methylation. However, endogene biosynthesis of choline does not ensure sufficient supply. Most vulnerable groups are menopausal women as well as people with certain polymorphisms in the metabolism of methionine, folate and choline. Hence, choline is a vitamin-like essential nutrient for humans. Therefore, a recommended adequate intake of choline was set at 400 to 425 mg per day for women and 400 to 550 mg per day for men. Choline is usually well tolerated even at an intake of several grams per day. The tolerable upper intake level (UL) for adults is 3.5 g of choline per day.
UR - http://www.scopus.com/inward/record.url?scp=85081904703&partnerID=8YFLogxK
M3 - Artikel
VL - 43
SP - 57
EP - 67
JO - Medizinische Monatsschrift fur Pharmazeuten
JF - Medizinische Monatsschrift fur Pharmazeuten
SN - 0342-9601
IS - 2
ER -