Details
| Original language | English |
|---|---|
| Pages (from-to) | 95-101 |
| Number of pages | 7 |
| Journal | Antioxidants & redox signaling |
| Volume | 5 |
| Issue number | 1 |
| Publication status | Published - Feb 2003 |
| Externally published | Yes |
Abstract
Chloroplasts are genetically semiautonomous organelles that contain their own subset of 100-120 genes coding for chloroplast proteins, tRNAs, and rRNAs. However, the great majority of the chloroplast proteins are encoded in the nucleus and must be imported into the organelle after their translation in the cytosol. This arrangement requires a high degree of coordination between the gene expression machineries in chloroplasts and nucleus, which is achieved by a permanent exchange of information between both compartments. The existence of such coordinating signals has long been known; however, the underlying molecular mechanisms and signaling routes are not understood. The present data indicate that the expression of nuclear-encoded chloroplast proteins is coupled to the functional state of the chloroplasts. Photosynthesis, which is the major function of chloroplasts, plays a crucial role in this context. Changes in the reduction/oxidation (redox) state of components of the photosynthetic machinery act as signals, which regulate the expression of chloroplast proteins in both chloroplasts and nucleus and help to coordinate the expression both in compartments. Recent advances in understanding chloroplast redox regulation of nuclear gene expression are summarized, and the importance for intracellular signaling is discussed.
Keywords
- Cell Nucleus/metabolism, Chloroplasts/metabolism, Gene Expression Regulation, Plant, Models, Biological, Oxidation-Reduction, Plastids/metabolism, RNA, Ribosomal/metabolism, RNA, Transfer/metabolism, Signal Transduction
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In: Antioxidants & redox signaling, Vol. 5, No. 1, 02.2003, p. 95-101.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Chloroplast redox control of nuclear gene expression--a new class of plastid signals in interorganellar communication
AU - Pfannschmidt, Thomas
AU - Schütze, Katia
AU - Fey, Vidal
AU - Sherameti, Irena
AU - Oelmüller, Ralf
PY - 2003/2
Y1 - 2003/2
N2 - Chloroplasts are genetically semiautonomous organelles that contain their own subset of 100-120 genes coding for chloroplast proteins, tRNAs, and rRNAs. However, the great majority of the chloroplast proteins are encoded in the nucleus and must be imported into the organelle after their translation in the cytosol. This arrangement requires a high degree of coordination between the gene expression machineries in chloroplasts and nucleus, which is achieved by a permanent exchange of information between both compartments. The existence of such coordinating signals has long been known; however, the underlying molecular mechanisms and signaling routes are not understood. The present data indicate that the expression of nuclear-encoded chloroplast proteins is coupled to the functional state of the chloroplasts. Photosynthesis, which is the major function of chloroplasts, plays a crucial role in this context. Changes in the reduction/oxidation (redox) state of components of the photosynthetic machinery act as signals, which regulate the expression of chloroplast proteins in both chloroplasts and nucleus and help to coordinate the expression both in compartments. Recent advances in understanding chloroplast redox regulation of nuclear gene expression are summarized, and the importance for intracellular signaling is discussed.
AB - Chloroplasts are genetically semiautonomous organelles that contain their own subset of 100-120 genes coding for chloroplast proteins, tRNAs, and rRNAs. However, the great majority of the chloroplast proteins are encoded in the nucleus and must be imported into the organelle after their translation in the cytosol. This arrangement requires a high degree of coordination between the gene expression machineries in chloroplasts and nucleus, which is achieved by a permanent exchange of information between both compartments. The existence of such coordinating signals has long been known; however, the underlying molecular mechanisms and signaling routes are not understood. The present data indicate that the expression of nuclear-encoded chloroplast proteins is coupled to the functional state of the chloroplasts. Photosynthesis, which is the major function of chloroplasts, plays a crucial role in this context. Changes in the reduction/oxidation (redox) state of components of the photosynthetic machinery act as signals, which regulate the expression of chloroplast proteins in both chloroplasts and nucleus and help to coordinate the expression both in compartments. Recent advances in understanding chloroplast redox regulation of nuclear gene expression are summarized, and the importance for intracellular signaling is discussed.
KW - Cell Nucleus/metabolism
KW - Chloroplasts/metabolism
KW - Gene Expression Regulation, Plant
KW - Models, Biological
KW - Oxidation-Reduction
KW - Plastids/metabolism
KW - RNA, Ribosomal/metabolism
KW - RNA, Transfer/metabolism
KW - Signal Transduction
U2 - 10.1089/152308603321223586
DO - 10.1089/152308603321223586
M3 - Review article
C2 - 12626121
VL - 5
SP - 95
EP - 101
JO - Antioxidants & redox signaling
JF - Antioxidants & redox signaling
SN - 1523-0864
IS - 1
ER -