Details
| Original language | English |
|---|---|
| Pages (from-to) | 4898-4901 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 46 |
| Issue number | 26 |
| Publication status | Published - 2007 |
Abstract
The best of both worlds: The configurational assignment of a natural product - chivosazole A (1) isolated from myxobacteria - has been achieved for the first time through the combination of structure elucidation and genetic analysis. This was achieved by chemical degradation, analysis of the NMR data in combination with computer-aided conformation analysis, and assignment of the amino acid sequence.
Keywords
- Configuration determination, Keto reductase, Molecular modeling, Natural products, NMR spectroscopy
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
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In: Angewandte Chemie - International Edition, Vol. 46, No. 26, 2007, p. 4898-4901.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Chivosazole A - Elucidation of the absolute and relative configuration
AU - Janssen, Dominic
AU - Albert, Dieter
AU - Jansen, Rolf
AU - Müller, Rolf
AU - Kalesse, Markus
PY - 2007
Y1 - 2007
N2 - The best of both worlds: The configurational assignment of a natural product - chivosazole A (1) isolated from myxobacteria - has been achieved for the first time through the combination of structure elucidation and genetic analysis. This was achieved by chemical degradation, analysis of the NMR data in combination with computer-aided conformation analysis, and assignment of the amino acid sequence.
AB - The best of both worlds: The configurational assignment of a natural product - chivosazole A (1) isolated from myxobacteria - has been achieved for the first time through the combination of structure elucidation and genetic analysis. This was achieved by chemical degradation, analysis of the NMR data in combination with computer-aided conformation analysis, and assignment of the amino acid sequence.
KW - Configuration determination
KW - Keto reductase
KW - Molecular modeling
KW - Natural products
KW - NMR spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=34447294842&partnerID=8YFLogxK
U2 - 10.1002/anie.200605198
DO - 10.1002/anie.200605198
M3 - Article
C2 - 17506055
AN - SCOPUS:34447294842
VL - 46
SP - 4898
EP - 4901
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 26
ER -