Details
| Original language | English |
|---|---|
| Pages (from-to) | 532-536 |
| Number of pages | 5 |
| Journal | Current Opinion in Chemical Biology |
| Volume | 17 |
| Issue number | 4 |
| Publication status | Published - 1 Aug 2013 |
Abstract
Tropolones are seven-membered aromatic rings which feature in the core of several important bioactive natural products including colchicine and stipitatic acid. Studies of their biosynthesis over nearly 70 years have revealed four parallel routes from polyketide, terpene, alkaloid and shikimate precursors, but the key steps all involve ring expansion of an alkylated 6-membered ring. Recent studies in fungi have revealed details of the individual chemical steps at the molecular level, but detailed molecular biosynthetic pathways in other organisms remain obscure.
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
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In: Current Opinion in Chemical Biology, Vol. 17, No. 4, 01.08.2013, p. 532-536.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Chemical mechanisms involved during the biosynthesis of tropolones
AU - Cox, Russell J.
AU - Al-Fahad, Ahmed
N1 - Funding information: Research into fungal tropolone biosynthesis in fungi has been supported by EPSRC (EP/F066104/1), the University of Bristol and Al Baha University (A. A-F.).
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Tropolones are seven-membered aromatic rings which feature in the core of several important bioactive natural products including colchicine and stipitatic acid. Studies of their biosynthesis over nearly 70 years have revealed four parallel routes from polyketide, terpene, alkaloid and shikimate precursors, but the key steps all involve ring expansion of an alkylated 6-membered ring. Recent studies in fungi have revealed details of the individual chemical steps at the molecular level, but detailed molecular biosynthetic pathways in other organisms remain obscure.
AB - Tropolones are seven-membered aromatic rings which feature in the core of several important bioactive natural products including colchicine and stipitatic acid. Studies of their biosynthesis over nearly 70 years have revealed four parallel routes from polyketide, terpene, alkaloid and shikimate precursors, but the key steps all involve ring expansion of an alkylated 6-membered ring. Recent studies in fungi have revealed details of the individual chemical steps at the molecular level, but detailed molecular biosynthetic pathways in other organisms remain obscure.
UR - http://www.scopus.com/inward/record.url?scp=84881230568&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2013.06.029
DO - 10.1016/j.cbpa.2013.06.029
M3 - Review article
C2 - 23870699
AN - SCOPUS:84881230568
VL - 17
SP - 532
EP - 536
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
SN - 1367-5931
IS - 4
ER -