Details
| Original language | English |
|---|---|
| Pages (from-to) | 59-64 |
| Number of pages | 6 |
| Journal | Journal of Optics A: Pure and Applied Optics |
| Volume | 2 |
| Issue number | 1 |
| Publication status | Published - 1 Jan 2000 |
Abstract
Focusing femtosecond (fs) laser pulses into transparent media, such as corneal tissue, leads to optical breakdown, generation of a micro-plasma and, thus, a cutting effect inside the tissue - provided the intensity at the focus exceeds a threshold which depends on the pulse duration. For fs pulses, the corresponding threshold pulse energy is reduced by some orders of magnitude compared with ns or ps pulses. At a low pulse energy, thermal and mechanical damage to surrounding tissue is minimized, enabling a highly precise cutting effect inside the tissue while leaving anterior layers unaltered. In the following, investigations concerning aspects of the interaction of ultrashort laser pulses with aqueous media are presented: in particular, detection of pressure transients and bubble formation. For the first time - to our knowledge - the content of the resulting gas bubbles was analyzed by gas chromatography, giving evidence of molecular hydrogen. Secondly, the potential of three-dimensional cutting effects within the corneal stroma for refractive surgery applications was evaluated in vitro on freshly enucleated porcine eyeglobes. Laser pulses with a duration of 200-300 fs and energies of 1.5-600 μJ were provided by a mode-locked Ti:sapphire laser with subsequent chirped pulse amplification.
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
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In: Journal of Optics A: Pure and Applied Optics, Vol. 2, No. 1, 01.01.2000, p. 59-64.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Chemical and physical side effects at application of ultrashort laser pulses for intrastromal refractive surgery
AU - Maatz, G.
AU - Heisterkamp, A.
AU - Lubatschowski, H.
AU - Barcikowski, S.
AU - Fallnich, C.
AU - Welling, H.
AU - Ertmer, W.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Focusing femtosecond (fs) laser pulses into transparent media, such as corneal tissue, leads to optical breakdown, generation of a micro-plasma and, thus, a cutting effect inside the tissue - provided the intensity at the focus exceeds a threshold which depends on the pulse duration. For fs pulses, the corresponding threshold pulse energy is reduced by some orders of magnitude compared with ns or ps pulses. At a low pulse energy, thermal and mechanical damage to surrounding tissue is minimized, enabling a highly precise cutting effect inside the tissue while leaving anterior layers unaltered. In the following, investigations concerning aspects of the interaction of ultrashort laser pulses with aqueous media are presented: in particular, detection of pressure transients and bubble formation. For the first time - to our knowledge - the content of the resulting gas bubbles was analyzed by gas chromatography, giving evidence of molecular hydrogen. Secondly, the potential of three-dimensional cutting effects within the corneal stroma for refractive surgery applications was evaluated in vitro on freshly enucleated porcine eyeglobes. Laser pulses with a duration of 200-300 fs and energies of 1.5-600 μJ were provided by a mode-locked Ti:sapphire laser with subsequent chirped pulse amplification.
AB - Focusing femtosecond (fs) laser pulses into transparent media, such as corneal tissue, leads to optical breakdown, generation of a micro-plasma and, thus, a cutting effect inside the tissue - provided the intensity at the focus exceeds a threshold which depends on the pulse duration. For fs pulses, the corresponding threshold pulse energy is reduced by some orders of magnitude compared with ns or ps pulses. At a low pulse energy, thermal and mechanical damage to surrounding tissue is minimized, enabling a highly precise cutting effect inside the tissue while leaving anterior layers unaltered. In the following, investigations concerning aspects of the interaction of ultrashort laser pulses with aqueous media are presented: in particular, detection of pressure transients and bubble formation. For the first time - to our knowledge - the content of the resulting gas bubbles was analyzed by gas chromatography, giving evidence of molecular hydrogen. Secondly, the potential of three-dimensional cutting effects within the corneal stroma for refractive surgery applications was evaluated in vitro on freshly enucleated porcine eyeglobes. Laser pulses with a duration of 200-300 fs and energies of 1.5-600 μJ were provided by a mode-locked Ti:sapphire laser with subsequent chirped pulse amplification.
UR - http://www.scopus.com/inward/record.url?scp=0033897122&partnerID=8YFLogxK
U2 - 10.1088/1464-4258/2/1/311
DO - 10.1088/1464-4258/2/1/311
M3 - Article
AN - SCOPUS:0033897122
VL - 2
SP - 59
EP - 64
JO - Journal of Optics A: Pure and Applied Optics
JF - Journal of Optics A: Pure and Applied Optics
SN - 1464-4258
IS - 1
ER -