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Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applicationsProvisionally accepted

Research output: Contribution to journal › Article › Research › peer review

Authors

  • Hüray Ilayda Kök
  • Tonya Andreeva
  • Sebastian Stammkötter
  • Cindy Reinholdt
  • Philipp Junker

Research Organisations

External Research Organisations

  • Reutlingen University
  • TU Dortmund University
  • Universitätsmedizin Rostock
  • Hannover Medical School (MHH)
  • Laser Zentrum Hannover e.V. (LZH)
  • University Medical Center Hamburg-Eppendorf

Details

Original languageEnglish
JournalFrontiers in Bioengineering and Biotechnology
Volume13
Publication statusAccepted/In press - 24 Feb 2025

Abstract

In the field of biomedical implants, additively manufactured titanium alloys, particularly Ti-6Al-4V, hold significant potential due to their biocompatibility and mechanical properties. This study focuses on the characterization and modeling of additively manufactured Ti-6Al-4V alloy for dental and maxillofacial implants, emphasizing fatigue behavior, surface modification, and their combined effects on cyto-and osseocompatibility. Experimental methods, including tensile, compression, and fatigue testing, were applied alongside in-silico simulations to assess the long-term mechanical performance of the material. Surface properties were further modified through sandblasting and coating techniques to enhance cell adhesion and proliferation. By using in-vitro methods, the cytocompatibility of the coatings and materials was examined followed by in-vivo tests to determine osseocompatibility. Results demonstrated that appropriate surface roughness and modifications are essential in optimizing osseointegration, while the layer-by-layer additive manufacturing process influenced the fatigue life and stability. These findings contribute to the development of patient-specific implants, optimizing both mechanical integrity and biological integration for enhanced clinical outcomes. This work summarizes the investigations on additively manufactured Ti-6Al-4V alloy of the research unit 5250 "Mechanism-based characterization and modeling of permanent and bioresorbable implants with tailored functionality based on innovative in vivo, in vitro and in silico methods" funded by the Germany Research Foundation (DFG).

Cite this

Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applicationsProvisionally accepted. / Kök, Hüray Ilayda; Andreeva, Tonya; Stammkötter, Sebastian et al.
In: Frontiers in Bioengineering and Biotechnology, Vol. 13, 24.02.2025.

Research output: Contribution to journal › Article › Research › peer review

Kök, HI, Andreeva, T, Stammkötter, S, Reinholdt, C, Akbas, O, Jahn, AM, Gamon, F, Fuest, S, Teschke, M, Schäfer, M, Müller, M, Koch, A, Jung, O, Barbeck, M, Greuling, A, Smeets, R, Hermsdorf, J, Krastev, R, Junker, P, Stiesch, M & Walther, F 2025, 'Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applicationsProvisionally accepted', Frontiers in Bioengineering and Biotechnology, vol. 13. https://doi.org/10.3389/fbioe.2025.1526873
Kök, H. I., Andreeva, T., Stammkötter, S., Reinholdt, C., Akbas, O., Jahn, A. M., Gamon, F., Fuest, S., Teschke, M., Schäfer, M., Müller, M., Koch, A., Jung, O., Barbeck, M., Greuling, A., Smeets, R., Hermsdorf, J., Krastev, R., Junker, P., ... Walther, F. (Accepted/in press). Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applicationsProvisionally accepted. Frontiers in Bioengineering and Biotechnology, 13. https://doi.org/10.3389/fbioe.2025.1526873
Kök HI, Andreeva T, Stammkötter S, Reinholdt C, Akbas O, Jahn AM et al. Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applicationsProvisionally accepted. Frontiers in Bioengineering and Biotechnology. 2025 Feb 24;13. doi: 10.3389/fbioe.2025.1526873
Kök, Hüray Ilayda ; Andreeva, Tonya ; Stammkötter, Sebastian et al. / Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applicationsProvisionally accepted. In: Frontiers in Bioengineering and Biotechnology. 2025 ; Vol. 13.
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title = "Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applicationsProvisionally accepted",
abstract = "In the field of biomedical implants, additively manufactured titanium alloys, particularly Ti-6Al-4V, hold significant potential due to their biocompatibility and mechanical properties. This study focuses on the characterization and modeling of additively manufactured Ti-6Al-4V alloy for dental and maxillofacial implants, emphasizing fatigue behavior, surface modification, and their combined effects on cyto-and osseocompatibility. Experimental methods, including tensile, compression, and fatigue testing, were applied alongside in-silico simulations to assess the long-term mechanical performance of the material. Surface properties were further modified through sandblasting and coating techniques to enhance cell adhesion and proliferation. By using in-vitro methods, the cytocompatibility of the coatings and materials was examined followed by in-vivo tests to determine osseocompatibility. Results demonstrated that appropriate surface roughness and modifications are essential in optimizing osseointegration, while the layer-by-layer additive manufacturing process influenced the fatigue life and stability. These findings contribute to the development of patient-specific implants, optimizing both mechanical integrity and biological integration for enhanced clinical outcomes. This work summarizes the investigations on additively manufactured Ti-6Al-4V alloy of the research unit 5250 {"}Mechanism-based characterization and modeling of permanent and bioresorbable implants with tailored functionality based on innovative in vivo, in vitro and in silico methods{"} funded by the Germany Research Foundation (DFG).",
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AU - Kök, Hüray Ilayda

AU - Andreeva, Tonya

AU - Stammkötter, Sebastian

AU - Reinholdt, Cindy

AU - Akbas, Osman

AU - Jahn, Anne Maren

AU - Gamon, Florian

AU - Fuest, Sandra

AU - Teschke, Mirko

AU - Schäfer, Mirijam

AU - Müller, Michael

AU - Koch, Alexander

AU - Jung, Ole

AU - Barbeck, Mike

AU - Greuling, Andreas

AU - Smeets, Ralf

AU - Hermsdorf, Jörg

AU - Krastev, Rumen

AU - Junker, Philipp

AU - Stiesch, Meike

AU - Walther, Frank

N1 - © 2025 Kök, Andreeva, Stammkötter, Reinholdt, Akbas, Jahn, Gamon, Fuest, Teschke, Schäfer, Michael, Koch, Jung, Barbeck, Greuling, Smeets, Hermsdrof, Krastev, Junker, Stiesch and Walther

PY - 2025/2/24

Y1 - 2025/2/24

N2 - In the field of biomedical implants, additively manufactured titanium alloys, particularly Ti-6Al-4V, hold significant potential due to their biocompatibility and mechanical properties. This study focuses on the characterization and modeling of additively manufactured Ti-6Al-4V alloy for dental and maxillofacial implants, emphasizing fatigue behavior, surface modification, and their combined effects on cyto-and osseocompatibility. Experimental methods, including tensile, compression, and fatigue testing, were applied alongside in-silico simulations to assess the long-term mechanical performance of the material. Surface properties were further modified through sandblasting and coating techniques to enhance cell adhesion and proliferation. By using in-vitro methods, the cytocompatibility of the coatings and materials was examined followed by in-vivo tests to determine osseocompatibility. Results demonstrated that appropriate surface roughness and modifications are essential in optimizing osseointegration, while the layer-by-layer additive manufacturing process influenced the fatigue life and stability. These findings contribute to the development of patient-specific implants, optimizing both mechanical integrity and biological integration for enhanced clinical outcomes. This work summarizes the investigations on additively manufactured Ti-6Al-4V alloy of the research unit 5250 "Mechanism-based characterization and modeling of permanent and bioresorbable implants with tailored functionality based on innovative in vivo, in vitro and in silico methods" funded by the Germany Research Foundation (DFG).

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U2 - 10.3389/fbioe.2025.1526873

DO - 10.3389/fbioe.2025.1526873

M3 - Article

VL - 13

JO - Frontiers in Bioengineering and Biotechnology

JF - Frontiers in Bioengineering and Biotechnology

SN - 2296-4185

ER -

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