Details
| Original language | English |
|---|---|
| Pages (from-to) | 27-29 |
| Number of pages | 3 |
| Journal | CHEMBIOCHEM |
| Volume | 15 |
| Issue number | 1 |
| Publication status | Published - 3 Jan 2014 |
Abstract
The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.
Keywords
- biosynthesis, branching, polyketides, rhizoxin
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Medicine
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Chemistry(all)
- Organic Chemistry
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In: CHEMBIOCHEM, Vol. 15, No. 1, 03.01.2014, p. 27-29.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - β-Chain extension
T2 - A new mode of carbon-carbon bond formation and chain extension by polyketide synthases
AU - Cox, Russell J.
PY - 2014/1/3
Y1 - 2014/1/3
N2 - The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.
AB - The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.
KW - biosynthesis
KW - branching
KW - polyketides
KW - rhizoxin
UR - http://www.scopus.com/inward/record.url?scp=84890800202&partnerID=8YFLogxK
U2 - 10.1002/cbic.201300660
DO - 10.1002/cbic.201300660
M3 - Review article
C2 - 24222633
AN - SCOPUS:84890800202
VL - 15
SP - 27
EP - 29
JO - CHEMBIOCHEM
JF - CHEMBIOCHEM
SN - 1439-4227
IS - 1
ER -