Details
| Original language | English |
|---|---|
| Pages (from-to) | 749-760 |
| Number of pages | 12 |
| Journal | Nature Reviews Microbiology |
| Volume | 13 |
| Issue number | 12 |
| Publication status | Published - 1 Dec 2015 |
| Externally published | Yes |
Abstract
The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling.
Keywords
- Cyclic GMP/analogs & derivatives, Gene Expression Regulation, Bacterial, Models, Biological, Signal Transduction, Spores, Bacterial/growth & development, Streptomycetaceae/cytology, Transcription Factors/metabolism
ASJC Scopus subject areas
- Medicine(all)
- Infectious Diseases
- Immunology and Microbiology(all)
- Immunology and Microbiology(all)
- Microbiology
Sustainable Development Goals
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In: Nature Reviews Microbiology, Vol. 13, No. 12, 01.12.2015, p. 749-760.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - c-di-GMP signalling and the regulation of developmental transitions in streptomycetes
AU - Bush, Matthew J
AU - Tschowri, Natalia
AU - Schlimpert, Susan
AU - Flärdh, Klas
AU - Buttner, Mark J
N1 - Publisher Copyright: © 2015 Macmillan Publishers Limited. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling.
AB - The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling.
KW - Cyclic GMP/analogs & derivatives
KW - Gene Expression Regulation, Bacterial
KW - Models, Biological
KW - Signal Transduction
KW - Spores, Bacterial/growth & development
KW - Streptomycetaceae/cytology
KW - Transcription Factors/metabolism
UR - http://www.scopus.com/inward/record.url?scp=84947486837&partnerID=8YFLogxK
U2 - 10.1038/nrmicro3546
DO - 10.1038/nrmicro3546
M3 - Article
C2 - 26499894
VL - 13
SP - 749
EP - 760
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
SN - 1740-1526
IS - 12
ER -