Details
| Original language | English |
|---|---|
| Article number | e12872 |
| Journal | Physiological Reports |
| Volume | 4 |
| Issue number | 14 |
| Publication status | Published - 1 Jul 2016 |
| Externally published | Yes |
Abstract
Recent studies have identified a predictable movement pattern of the common carotid artery wall in the longitudinal direction. While there is evidence that the magnitude of this carotid artery longitudinal wall motion (CALM) is sensitive to cardiovascular health status, little is known about the determinants of CALM. The purpose of this integrative study was to evaluate the contribution of left ventricular (LV) cardiac motion and local blood velocity to CALM. Simultaneous ultrasound measurements of CALM, common carotid artery mean blood velocity (MBV), and left ventricular motion were performed in ten young, healthy individuals (6 males; 22 ± 1 years). Peak anterograde CALM occurred at a similar time as peak MBV (18.57 ± 3.98% vs. 18.53 ± 2.81% cardiac cycle; t-test: P = 0.94; ICC: 0.79, P < 0.01). The timing of maximum retrograde CALM displacement was different, but related, to both peak apical (41.00 ± 7.81% vs. 35.33 ± 5.79% cardiac cycle; t-test: P < 0.01; ICC: 0.79, P < 0.01) and basal rotation (41.80 ± 6.12% vs. 37.30 ± 5.66% cardiac cycle; t-test: P < 0.01; ICC: 0.74, P < 0.01) with peak cardiac displacements preceding peak CALM displacements in both cases. The association between basal rotation and retrograde CALM was further supported by strong correlations between their peak magnitudes (r = −0.70, P = 0.02), whereas the magnitude of septal longitudinal displacement was not associated with peak CALM (r = 0.11, P = 0.77). These results suggest that the rotational mechanical movement of the LV base may be closely associated with longitudinal mechanics in the carotid artery. This finding may have important implications for interpreting the complex relationship between ventricular and vascular function.
Keywords
- Carotid artery longitudinal wall motion, left ventricular rotation, ultrasound
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Physiology
- Medicine(all)
- Physiology (medical)
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In: Physiological Reports, Vol. 4, No. 14, e12872, 01.07.2016.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Carotid artery longitudinal wall motion is associated with local blood velocity and left ventricular rotational, but not longitudinal, mechanics
AU - Au, Jason S.
AU - Ditor, David S.
AU - MacDonald, Maureen J.
AU - Stöhr, Eric J.
N1 - Publisher Copyright: © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Recent studies have identified a predictable movement pattern of the common carotid artery wall in the longitudinal direction. While there is evidence that the magnitude of this carotid artery longitudinal wall motion (CALM) is sensitive to cardiovascular health status, little is known about the determinants of CALM. The purpose of this integrative study was to evaluate the contribution of left ventricular (LV) cardiac motion and local blood velocity to CALM. Simultaneous ultrasound measurements of CALM, common carotid artery mean blood velocity (MBV), and left ventricular motion were performed in ten young, healthy individuals (6 males; 22 ± 1 years). Peak anterograde CALM occurred at a similar time as peak MBV (18.57 ± 3.98% vs. 18.53 ± 2.81% cardiac cycle; t-test: P = 0.94; ICC: 0.79, P < 0.01). The timing of maximum retrograde CALM displacement was different, but related, to both peak apical (41.00 ± 7.81% vs. 35.33 ± 5.79% cardiac cycle; t-test: P < 0.01; ICC: 0.79, P < 0.01) and basal rotation (41.80 ± 6.12% vs. 37.30 ± 5.66% cardiac cycle; t-test: P < 0.01; ICC: 0.74, P < 0.01) with peak cardiac displacements preceding peak CALM displacements in both cases. The association between basal rotation and retrograde CALM was further supported by strong correlations between their peak magnitudes (r = −0.70, P = 0.02), whereas the magnitude of septal longitudinal displacement was not associated with peak CALM (r = 0.11, P = 0.77). These results suggest that the rotational mechanical movement of the LV base may be closely associated with longitudinal mechanics in the carotid artery. This finding may have important implications for interpreting the complex relationship between ventricular and vascular function.
AB - Recent studies have identified a predictable movement pattern of the common carotid artery wall in the longitudinal direction. While there is evidence that the magnitude of this carotid artery longitudinal wall motion (CALM) is sensitive to cardiovascular health status, little is known about the determinants of CALM. The purpose of this integrative study was to evaluate the contribution of left ventricular (LV) cardiac motion and local blood velocity to CALM. Simultaneous ultrasound measurements of CALM, common carotid artery mean blood velocity (MBV), and left ventricular motion were performed in ten young, healthy individuals (6 males; 22 ± 1 years). Peak anterograde CALM occurred at a similar time as peak MBV (18.57 ± 3.98% vs. 18.53 ± 2.81% cardiac cycle; t-test: P = 0.94; ICC: 0.79, P < 0.01). The timing of maximum retrograde CALM displacement was different, but related, to both peak apical (41.00 ± 7.81% vs. 35.33 ± 5.79% cardiac cycle; t-test: P < 0.01; ICC: 0.79, P < 0.01) and basal rotation (41.80 ± 6.12% vs. 37.30 ± 5.66% cardiac cycle; t-test: P < 0.01; ICC: 0.74, P < 0.01) with peak cardiac displacements preceding peak CALM displacements in both cases. The association between basal rotation and retrograde CALM was further supported by strong correlations between their peak magnitudes (r = −0.70, P = 0.02), whereas the magnitude of septal longitudinal displacement was not associated with peak CALM (r = 0.11, P = 0.77). These results suggest that the rotational mechanical movement of the LV base may be closely associated with longitudinal mechanics in the carotid artery. This finding may have important implications for interpreting the complex relationship between ventricular and vascular function.
KW - Carotid artery longitudinal wall motion
KW - left ventricular rotation
KW - ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84979555126&partnerID=8YFLogxK
U2 - 10.14814/phy2.12872
DO - 10.14814/phy2.12872
M3 - Article
C2 - 27440745
AN - SCOPUS:84979555126
VL - 4
JO - Physiological Reports
JF - Physiological Reports
IS - 14
M1 - e12872
ER -