Details
| Original language | English |
|---|---|
| Pages (from-to) | 518-526 |
| Number of pages | 9 |
| Journal | HEART |
| Volume | 102 |
| Issue number | 7 |
| Early online date | 21 Jan 2016 |
| Publication status | Published - Apr 2016 |
| Externally published | Yes |
Abstract
Objective Cardiac output, a fundamental parameter of cardiovascular function, has consistently been shown to increase across healthy pregnancy; however, the time course and magnitude of adaptation remains equivocal within published literature. The aim of the present metaanalyses was to comprehensively describe the pattern of change in cardiac output during healthy pregnancy. Method A series of meta-analyses of previously published cardiac output data during healthy, singleton pregnancies was completed. PubMed and Scopus databases were searched for studies published between 1996 and 2014. Included studies reported absolute values during a predetermined gestational age (nonpregnant, late first trimester, early and late second trimester, early and late third trimester, early and late postpartum). Cardiac output was measured through echocardiography, impedance cardiography or inert gas rebreathing. Observational data were meta-analysed at each gestational age using a random-effects model. If reported, related haemodynamic variables were evaluated. Results In total, 39 studies were eligible for inclusion, with pooled sample sizes ranging from 259 to 748. Cardiac output increased during pregnancy reaching its peak in the early third trimester, 1.5 L/min (31%) above non-pregnant values. The observed results from this study indicated a non-linear rise to this point. In the early postpartum, cardiac output had returned to nonpregnant values. Conclusion The present results suggest that cardiac output peaks in the early third trimester, following a non-linear pattern of adaptation; however, this must be confirmed using longitudinal studies. The findings provide new insight into the normal progression of cardiac output during pregnancy.
ASJC Scopus subject areas
- Medicine(all)
- Cardiology and Cardiovascular Medicine
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In: HEART, Vol. 102, No. 7, 04.2016, p. 518-526.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Cardiac output and related haemodynamics during pregnancy
T2 - a series of meta-analyses
AU - Meah, Victoria L.
AU - Cockcroft, John R.
AU - Backx, Karianne
AU - Shave, Rob
AU - Stöhr, Eric J.
PY - 2016/4
Y1 - 2016/4
N2 - Objective Cardiac output, a fundamental parameter of cardiovascular function, has consistently been shown to increase across healthy pregnancy; however, the time course and magnitude of adaptation remains equivocal within published literature. The aim of the present metaanalyses was to comprehensively describe the pattern of change in cardiac output during healthy pregnancy. Method A series of meta-analyses of previously published cardiac output data during healthy, singleton pregnancies was completed. PubMed and Scopus databases were searched for studies published between 1996 and 2014. Included studies reported absolute values during a predetermined gestational age (nonpregnant, late first trimester, early and late second trimester, early and late third trimester, early and late postpartum). Cardiac output was measured through echocardiography, impedance cardiography or inert gas rebreathing. Observational data were meta-analysed at each gestational age using a random-effects model. If reported, related haemodynamic variables were evaluated. Results In total, 39 studies were eligible for inclusion, with pooled sample sizes ranging from 259 to 748. Cardiac output increased during pregnancy reaching its peak in the early third trimester, 1.5 L/min (31%) above non-pregnant values. The observed results from this study indicated a non-linear rise to this point. In the early postpartum, cardiac output had returned to nonpregnant values. Conclusion The present results suggest that cardiac output peaks in the early third trimester, following a non-linear pattern of adaptation; however, this must be confirmed using longitudinal studies. The findings provide new insight into the normal progression of cardiac output during pregnancy.
AB - Objective Cardiac output, a fundamental parameter of cardiovascular function, has consistently been shown to increase across healthy pregnancy; however, the time course and magnitude of adaptation remains equivocal within published literature. The aim of the present metaanalyses was to comprehensively describe the pattern of change in cardiac output during healthy pregnancy. Method A series of meta-analyses of previously published cardiac output data during healthy, singleton pregnancies was completed. PubMed and Scopus databases were searched for studies published between 1996 and 2014. Included studies reported absolute values during a predetermined gestational age (nonpregnant, late first trimester, early and late second trimester, early and late third trimester, early and late postpartum). Cardiac output was measured through echocardiography, impedance cardiography or inert gas rebreathing. Observational data were meta-analysed at each gestational age using a random-effects model. If reported, related haemodynamic variables were evaluated. Results In total, 39 studies were eligible for inclusion, with pooled sample sizes ranging from 259 to 748. Cardiac output increased during pregnancy reaching its peak in the early third trimester, 1.5 L/min (31%) above non-pregnant values. The observed results from this study indicated a non-linear rise to this point. In the early postpartum, cardiac output had returned to nonpregnant values. Conclusion The present results suggest that cardiac output peaks in the early third trimester, following a non-linear pattern of adaptation; however, this must be confirmed using longitudinal studies. The findings provide new insight into the normal progression of cardiac output during pregnancy.
UR - http://www.scopus.com/inward/record.url?scp=84956624929&partnerID=8YFLogxK
U2 - 10.1136/heartjnl-2015-308476
DO - 10.1136/heartjnl-2015-308476
M3 - Article
C2 - 26794234
AN - SCOPUS:84956624929
VL - 102
SP - 518
EP - 526
JO - HEART
JF - HEART
SN - 1355-6037
IS - 7
ER -