Details
| Original language | English |
|---|---|
| Pages (from-to) | 213-220 |
| Number of pages | 8 |
| Journal | European Journal of Clinical Investigation |
| Volume | 47 |
| Issue number | 3 |
| Publication status | Published - Mar 2017 |
| Externally published | Yes |
| Event | 19th Annual Congress of the European College of Sport Science - Amsterdam, Netherlands Duration: 2 Jul 2014 → 5 Jul 2014 |
Abstract
Background: The cardiac dysfunction associated with anthracycline-based chemotherapy cancer treatment can exist subclinically for decades before overt presentation. Stress echocardiography, the measurement of left ventricular (LV) deformation and arterial haemodynamic evaluation, has separately been used to identify subclinical cardiovascular (CV) dysfunction in several patient groups including those with hypertension and diabetes. The purpose of the present cross-sectional study was to determine whether the combination of these techniques could be used to improve the characterisation of subclinical CV dysfunction in long-term cancer survivors previously treated with anthracyclines. Materials and methods: Thirteen long-term cancer survivors (36 ± 10 years) with prior anthracycline exposure (11 ± 8 years posttreatment) and 13 age-matched controls were recruited. Left ventricular structure, function and deformation were assessed using echocardiography. Augmentation index was used to quantify arterial haemodynamic load and was measured using applanation tonometry. Measurements were taken at rest and during two stages of low-intensity incremental cycling. Results: At rest, both groups had comparable global LV systolic, diastolic and arterial function (all P > 0·05); however, longitudinal deformation was significantly lower in cancer survivors (−18 ± 2 vs. −20 ± 2, P < 0·05). During exercise, this difference between groups persisted and further differences were uncovered with significantly lower apical circumferential deformation in the cancer survivors (−24 ± 5 vs. −29 ± 5, −29 ± 5 vs. 35 ± 8 for first and second stage of exercise respectively, both P < 0·05). Conclusion: In contrast to resting echocardiography, the measurement of LV deformation at rest and during exercise provides a more comprehensive characterisation of subclinical LV dysfunction. Larger studies are required to determine the clinical relevance of these preliminary findings.
Keywords
- Anthracyclines, arterial haemodynamics, cardiac deformation, exercise echocardiography
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Clinical Biochemistry
Sustainable Development Goals
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In: European Journal of Clinical Investigation, Vol. 47, No. 3, 03.2017, p. 213-220.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Cardiac dysfunction in cancer survivors unmasked during exercise
AU - Kearney, Maria C.
AU - Gallop-Evans, Eve
AU - Cockcroft, John R.
AU - Stöhr, Eric J.
AU - Lee, Eveline
AU - Backx, Karianne
AU - Haykowsky, Mark
AU - Yousef, Zaheer
AU - Shave, Rob
PY - 2017/3
Y1 - 2017/3
N2 - Background: The cardiac dysfunction associated with anthracycline-based chemotherapy cancer treatment can exist subclinically for decades before overt presentation. Stress echocardiography, the measurement of left ventricular (LV) deformation and arterial haemodynamic evaluation, has separately been used to identify subclinical cardiovascular (CV) dysfunction in several patient groups including those with hypertension and diabetes. The purpose of the present cross-sectional study was to determine whether the combination of these techniques could be used to improve the characterisation of subclinical CV dysfunction in long-term cancer survivors previously treated with anthracyclines. Materials and methods: Thirteen long-term cancer survivors (36 ± 10 years) with prior anthracycline exposure (11 ± 8 years posttreatment) and 13 age-matched controls were recruited. Left ventricular structure, function and deformation were assessed using echocardiography. Augmentation index was used to quantify arterial haemodynamic load and was measured using applanation tonometry. Measurements were taken at rest and during two stages of low-intensity incremental cycling. Results: At rest, both groups had comparable global LV systolic, diastolic and arterial function (all P > 0·05); however, longitudinal deformation was significantly lower in cancer survivors (−18 ± 2 vs. −20 ± 2, P < 0·05). During exercise, this difference between groups persisted and further differences were uncovered with significantly lower apical circumferential deformation in the cancer survivors (−24 ± 5 vs. −29 ± 5, −29 ± 5 vs. 35 ± 8 for first and second stage of exercise respectively, both P < 0·05). Conclusion: In contrast to resting echocardiography, the measurement of LV deformation at rest and during exercise provides a more comprehensive characterisation of subclinical LV dysfunction. Larger studies are required to determine the clinical relevance of these preliminary findings.
AB - Background: The cardiac dysfunction associated with anthracycline-based chemotherapy cancer treatment can exist subclinically for decades before overt presentation. Stress echocardiography, the measurement of left ventricular (LV) deformation and arterial haemodynamic evaluation, has separately been used to identify subclinical cardiovascular (CV) dysfunction in several patient groups including those with hypertension and diabetes. The purpose of the present cross-sectional study was to determine whether the combination of these techniques could be used to improve the characterisation of subclinical CV dysfunction in long-term cancer survivors previously treated with anthracyclines. Materials and methods: Thirteen long-term cancer survivors (36 ± 10 years) with prior anthracycline exposure (11 ± 8 years posttreatment) and 13 age-matched controls were recruited. Left ventricular structure, function and deformation were assessed using echocardiography. Augmentation index was used to quantify arterial haemodynamic load and was measured using applanation tonometry. Measurements were taken at rest and during two stages of low-intensity incremental cycling. Results: At rest, both groups had comparable global LV systolic, diastolic and arterial function (all P > 0·05); however, longitudinal deformation was significantly lower in cancer survivors (−18 ± 2 vs. −20 ± 2, P < 0·05). During exercise, this difference between groups persisted and further differences were uncovered with significantly lower apical circumferential deformation in the cancer survivors (−24 ± 5 vs. −29 ± 5, −29 ± 5 vs. 35 ± 8 for first and second stage of exercise respectively, both P < 0·05). Conclusion: In contrast to resting echocardiography, the measurement of LV deformation at rest and during exercise provides a more comprehensive characterisation of subclinical LV dysfunction. Larger studies are required to determine the clinical relevance of these preliminary findings.
KW - Anthracyclines
KW - arterial haemodynamics
KW - cardiac deformation
KW - exercise echocardiography
UR - http://www.scopus.com/inward/record.url?scp=85011022985&partnerID=8YFLogxK
U2 - 10.1111/eci.12720
DO - 10.1111/eci.12720
M3 - Article
C2 - 28036108
AN - SCOPUS:85011022985
VL - 47
SP - 213
EP - 220
JO - European Journal of Clinical Investigation
JF - European Journal of Clinical Investigation
SN - 0014-2972
IS - 3
T2 - 19th Annual Congress of the European College of Sport Science
Y2 - 2 July 2014 through 5 July 2014
ER -