Details
| Original language | English |
|---|---|
| Pages (from-to) | 1659-1683 |
| Number of pages | 25 |
| Journal | Natural product reports |
| Volume | 38 |
| Issue number | 9 |
| Early online date | 23 Feb 2021 |
| Publication status | Published - 1 Sept 2021 |
| Externally published | Yes |
Abstract
Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a d-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009-2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural product reports, Vol. 38, No. 9, 01.09.2021, p. 1659-1683.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Bottromycins - Biosynthesis, synthesis and activity
AU - Franz, Laura
AU - Kazmaier, Uli
AU - Truman, Andrew W.
AU - Koehnke, Jesko
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a d-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009-2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.
AB - Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a d-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009-2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.
UR - http://www.scopus.com/inward/record.url?scp=85110092026&partnerID=8YFLogxK
U2 - 10.1039/d0np00097c
DO - 10.1039/d0np00097c
M3 - Review article
C2 - 33621290
AN - SCOPUS:85110092026
VL - 38
SP - 1659
EP - 1683
JO - Natural product reports
JF - Natural product reports
SN - 0265-0568
IS - 9
ER -