Details
| Original language | English |
|---|---|
| Pages (from-to) | 1005-1011 |
| Number of pages | 7 |
| Journal | Liebigs Annales |
| Issue number | 5 |
| Publication status | Published - May 1997 |
Abstract
Various bis(guanidinium) compounds have been synthesized and their abilities to cleave the RNA model compound HPNPP have been tested in acetonitrile and in water. Depending on the spacer length, the substitution of the guanidinium groups, and the presence of an internal base, different rate constants for the transesterification of HPNPP are observed in these two media. The steroid derived bis(guanidinium) compound 12 was identified as a superior system.
Keywords
- Bis(guanidinium) compounds, Cleavage reactions, Enzyme mimetics, Phosphatase, Solvent effects, Steroids
ASJC Scopus subject areas
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In: Liebigs Annales, No. 5, 05.1997, p. 1005-1011.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Bis(guanidinium) receptors as ribonuclease active-site model systems
T2 - Structural changes and solvent effects
AU - Oost, Thorsten
AU - Filippazzi, Anna
AU - Kalesse, Markus
PY - 1997/5
Y1 - 1997/5
N2 - Various bis(guanidinium) compounds have been synthesized and their abilities to cleave the RNA model compound HPNPP have been tested in acetonitrile and in water. Depending on the spacer length, the substitution of the guanidinium groups, and the presence of an internal base, different rate constants for the transesterification of HPNPP are observed in these two media. The steroid derived bis(guanidinium) compound 12 was identified as a superior system.
AB - Various bis(guanidinium) compounds have been synthesized and their abilities to cleave the RNA model compound HPNPP have been tested in acetonitrile and in water. Depending on the spacer length, the substitution of the guanidinium groups, and the presence of an internal base, different rate constants for the transesterification of HPNPP are observed in these two media. The steroid derived bis(guanidinium) compound 12 was identified as a superior system.
KW - Bis(guanidinium) compounds
KW - Cleavage reactions
KW - Enzyme mimetics
KW - Phosphatase
KW - Solvent effects
KW - Steroids
UR - http://www.scopus.com/inward/record.url?scp=33749089117&partnerID=8YFLogxK
U2 - 10.1002/jlac.199719970532
DO - 10.1002/jlac.199719970532
M3 - Article
AN - SCOPUS:33749089117
SP - 1005
EP - 1011
JO - Liebigs Annales
JF - Liebigs Annales
SN - 0947-3440
IS - 5
ER -