Details
| Original language | English |
|---|---|
| Title of host publication | Tissue Engineering |
| Editors | Jan De Boer, Clemens A Van Blitterswijk |
| Publisher | Elsevier |
| Pages | 431-456 |
| Number of pages | 26 |
| Edition | 3 |
| ISBN (electronic) | 9780128244593 |
| ISBN (print) | 9780323851343 |
| Publication status | Published - 20 Jan 2023 |
| Externally published | Yes |
Abstract
This chapter gives a general overview on the basic requirements for designing bioreactors for tissue engineering. It comprises the general components of a bioreactor and discusses the choice of suitable culture parameters for a tissue engineering process. Furthermore, the necessity to mimic physiologic conditions with the help of bioreactor systems in order to achieve sufficient tissue maturation is explained. As cell expansion is a prerequisite for tissue engineering processes, this chapter covers also bioreactors for expansion of cells and the issue of scale-up versus scale-out. Finally, commercially available bioreactor systems for the application of defined mechanical forces for tissue engineering processes are presented and discussed.
Keywords
- Bioreactor components, Cell expansion, Differentiation, Mechanical forces, Physiological culture conditions
ASJC Scopus subject areas
Cite this
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Tissue Engineering. ed. / Jan De Boer; Clemens A Van Blitterswijk. 3. ed. Elsevier, 2023. p. 431-456.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - Bioreactors
T2 - enabling technologies for research and manufacturing
AU - Egger, Dominik
AU - Nebel, Sabrina
AU - Gensler, Marius
AU - Kreß, Sebastian
AU - Hansmann, Jan
AU - Kasper, Cornelia
PY - 2023/1/20
Y1 - 2023/1/20
N2 - This chapter gives a general overview on the basic requirements for designing bioreactors for tissue engineering. It comprises the general components of a bioreactor and discusses the choice of suitable culture parameters for a tissue engineering process. Furthermore, the necessity to mimic physiologic conditions with the help of bioreactor systems in order to achieve sufficient tissue maturation is explained. As cell expansion is a prerequisite for tissue engineering processes, this chapter covers also bioreactors for expansion of cells and the issue of scale-up versus scale-out. Finally, commercially available bioreactor systems for the application of defined mechanical forces for tissue engineering processes are presented and discussed.
AB - This chapter gives a general overview on the basic requirements for designing bioreactors for tissue engineering. It comprises the general components of a bioreactor and discusses the choice of suitable culture parameters for a tissue engineering process. Furthermore, the necessity to mimic physiologic conditions with the help of bioreactor systems in order to achieve sufficient tissue maturation is explained. As cell expansion is a prerequisite for tissue engineering processes, this chapter covers also bioreactors for expansion of cells and the issue of scale-up versus scale-out. Finally, commercially available bioreactor systems for the application of defined mechanical forces for tissue engineering processes are presented and discussed.
KW - Bioreactor components
KW - Cell expansion
KW - Differentiation
KW - Mechanical forces
KW - Physiological culture conditions
UR - http://www.scopus.com/inward/record.url?scp=85149751473&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-824459-3.00013-5
DO - 10.1016/B978-0-12-824459-3.00013-5
M3 - Contribution to book/anthology
AN - SCOPUS:85149751473
SN - 9780323851343
SP - 431
EP - 456
BT - Tissue Engineering
A2 - De Boer, Jan
A2 - Van Blitterswijk, Clemens A
PB - Elsevier
ER -