Details
| Original language | English |
|---|---|
| Pages (from-to) | 5547-5553 |
| Number of pages | 7 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 10 |
| Issue number | 29 |
| Publication status | Published - 7 Aug 2012 |
Abstract
"Click" reactions have become very common and powerful ligation techniques, of which 1,3-dipolar cycloadditions have most frequently been employed. Since metal-mediated cycloadditions are incompatible in biomedical applications due to toxicity issues associated with transition metals like copper, metal-free variants provide important alternatives. The metal-free conjugation process is studied in detail with special emphasis put on the reaction progress. This report unfolds the first aqueous metal-free "click" conjugation of a cyclic RGD-pentapeptide with the biomacromolecule alginate, creating a "smart" bioactive polymer with potential applications in biomedicine.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemistry(all)
- Organic Chemistry
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In: Organic and Biomolecular Chemistry, Vol. 10, No. 29, 07.08.2012, p. 5547-5553.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate
AU - Krause, Andreas
AU - Kirschning, Andreas
AU - Dräger, Gerald
PY - 2012/8/7
Y1 - 2012/8/7
N2 - "Click" reactions have become very common and powerful ligation techniques, of which 1,3-dipolar cycloadditions have most frequently been employed. Since metal-mediated cycloadditions are incompatible in biomedical applications due to toxicity issues associated with transition metals like copper, metal-free variants provide important alternatives. The metal-free conjugation process is studied in detail with special emphasis put on the reaction progress. This report unfolds the first aqueous metal-free "click" conjugation of a cyclic RGD-pentapeptide with the biomacromolecule alginate, creating a "smart" bioactive polymer with potential applications in biomedicine.
AB - "Click" reactions have become very common and powerful ligation techniques, of which 1,3-dipolar cycloadditions have most frequently been employed. Since metal-mediated cycloadditions are incompatible in biomedical applications due to toxicity issues associated with transition metals like copper, metal-free variants provide important alternatives. The metal-free conjugation process is studied in detail with special emphasis put on the reaction progress. This report unfolds the first aqueous metal-free "click" conjugation of a cyclic RGD-pentapeptide with the biomacromolecule alginate, creating a "smart" bioactive polymer with potential applications in biomedicine.
UR - http://www.scopus.com/inward/record.url?scp=84863607142&partnerID=8YFLogxK
U2 - 10.1039/c2ob25604e
DO - 10.1039/c2ob25604e
M3 - Article
C2 - 22714573
AN - SCOPUS:84863607142
VL - 10
SP - 5547
EP - 5553
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 29
ER -