Details
| Original language | English |
|---|---|
| Journal | FEMS microbiology ecology |
| Volume | 93 |
| Issue number | 3 |
| Publication status | Published - 2 Feb 2017 |
Abstract
For decades, extensive research efforts have been conducted to improve the functionality and stability of implants. Especially in dentistry, implant treatment has become a standard medical practice. The treatment restores full dental functionality, helping patients to maintain high quality of life. However, about 10% of the patients suffer from early and late device failure due to peri-implantitis, an inflammatory disease of the tissues surrounding the implant. Peri-implantitis is caused by progressive microbial colonization of the device surface and the formation of microbial communities, so-called biofilms. This infection can ultimately lead to implant failure. The causative agents for the inflammatory disease, periodontal pathogenic biofilms, have already been extensively studied, but are still not completely understood. As numerical simulations will have the potential to predict oral biofilm formation precisely in the future, for the first time, this study aimed to analyze Streptococcus gordonii biofilms by combining experimental studies and numerical simulation. The study demonstrated that numerical simulation was able to precisely model the influence of different nutrient concentration and spatial distribution of active and inactive biomass of the biofilm in comparison with the experimental data. This model may provide a less time-consuming method for the future investigation of any bacterial biofilm.
Keywords
- Bacterial biofilm, Flow chamber system, Implant-associated infection, Model validation, Numerical simulation, Streptococcus gordonii
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Microbiology
- Environmental Science(all)
- Ecology
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
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In: FEMS microbiology ecology, Vol. 93, No. 3, 02.02.2017.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Biofilm formation by the oral pioneer colonizer Streptococcus gordonii
T2 - An experimental and numerical study
AU - Rath, Henryke
AU - Feng, Dianlei
AU - Neuweiler, Insa
AU - Stumpp, Nico S.
AU - Nackenhorst, Udo
AU - Stiesch, Meike
PY - 2017/2/2
Y1 - 2017/2/2
N2 - For decades, extensive research efforts have been conducted to improve the functionality and stability of implants. Especially in dentistry, implant treatment has become a standard medical practice. The treatment restores full dental functionality, helping patients to maintain high quality of life. However, about 10% of the patients suffer from early and late device failure due to peri-implantitis, an inflammatory disease of the tissues surrounding the implant. Peri-implantitis is caused by progressive microbial colonization of the device surface and the formation of microbial communities, so-called biofilms. This infection can ultimately lead to implant failure. The causative agents for the inflammatory disease, periodontal pathogenic biofilms, have already been extensively studied, but are still not completely understood. As numerical simulations will have the potential to predict oral biofilm formation precisely in the future, for the first time, this study aimed to analyze Streptococcus gordonii biofilms by combining experimental studies and numerical simulation. The study demonstrated that numerical simulation was able to precisely model the influence of different nutrient concentration and spatial distribution of active and inactive biomass of the biofilm in comparison with the experimental data. This model may provide a less time-consuming method for the future investigation of any bacterial biofilm.
AB - For decades, extensive research efforts have been conducted to improve the functionality and stability of implants. Especially in dentistry, implant treatment has become a standard medical practice. The treatment restores full dental functionality, helping patients to maintain high quality of life. However, about 10% of the patients suffer from early and late device failure due to peri-implantitis, an inflammatory disease of the tissues surrounding the implant. Peri-implantitis is caused by progressive microbial colonization of the device surface and the formation of microbial communities, so-called biofilms. This infection can ultimately lead to implant failure. The causative agents for the inflammatory disease, periodontal pathogenic biofilms, have already been extensively studied, but are still not completely understood. As numerical simulations will have the potential to predict oral biofilm formation precisely in the future, for the first time, this study aimed to analyze Streptococcus gordonii biofilms by combining experimental studies and numerical simulation. The study demonstrated that numerical simulation was able to precisely model the influence of different nutrient concentration and spatial distribution of active and inactive biomass of the biofilm in comparison with the experimental data. This model may provide a less time-consuming method for the future investigation of any bacterial biofilm.
KW - Bacterial biofilm
KW - Flow chamber system
KW - Implant-associated infection
KW - Model validation
KW - Numerical simulation
KW - Streptococcus gordonii
UR - http://www.scopus.com/inward/record.url?scp=85029735426&partnerID=8YFLogxK
U2 - 10.1093/femsec/fix010
DO - 10.1093/femsec/fix010
M3 - Article
C2 - 28158402
AN - SCOPUS:85029735426
VL - 93
JO - FEMS microbiology ecology
JF - FEMS microbiology ecology
SN - 0168-6496
IS - 3
ER -