Details
| Original language | English |
|---|---|
| Pages (from-to) | 350-365 |
| Number of pages | 16 |
| Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
| Volume | 105 |
| Issue number | 2 |
| Publication status | Published - 29 Oct 2015 |
Abstract
Despite innovative surgical techniques and use of current frontal sinus stents from different materials, the problem of treatment failure with consecutive reoperation remains present. The aim of our study is to investigate biocompatibility, degradation kinetics, and functionality of a newly developed fluoride-coated magnesium-based nasal stent. A minipig anatomy of frontal sinus adapted design and an external surgical approach were developed and established. The functionality of the stents was evaluated endoscopically. The stent-tissue blocks were analysed after 90 and 180 days using microcomputed tomography (µ-CT), histology, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS). Functional evaluation revealed an unobstructed stent lumen in all cases. Histological analysis showed moderate mucosal hyperplasia with a mild, nonspecific inflammatory response, and nonosteoconductive effect. Rejection reactions or necrosis did not occur. The volumetric analysis of the stents showed 51% volume loss after 180 days. The EDS analysis did not detect any neodymium (Nd) in the mucosa or bone. The Mg–2 wt % Nd stents are a promising option when treating the narrow passages following paranasal sinus surgery. In particular, its good biocompatibility and good functionality facilitate the re-epithelization of these constricted passages.
Keywords
- biocompatibility, ENT surgery, magnesium, mucosa, nasal stent
ASJC Scopus subject areas
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
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In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 105, No. 2, 29.10.2015, p. 350-365.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Biodegradable nasal stents (MgF2-coated Mg–2 wt %Nd alloy)
T2 - A long-term in vivo study
AU - Durisin, Martin
AU - Reifenrath, Janin
AU - Weber, Constantin M.
AU - Eifler, Rainer
AU - Maier, Hans J.
AU - Lenarz, Thomas
AU - Seitz, Jan Marten
N1 - Funding information: This study was conducted within the Collaborative Research Centre SFB 599 (Project R1). Special thanks go to Melanie Kielhorn and Melanie Steffens for their extremely valuable technical support. German Research Foundation (DFG)
PY - 2015/10/29
Y1 - 2015/10/29
N2 - Despite innovative surgical techniques and use of current frontal sinus stents from different materials, the problem of treatment failure with consecutive reoperation remains present. The aim of our study is to investigate biocompatibility, degradation kinetics, and functionality of a newly developed fluoride-coated magnesium-based nasal stent. A minipig anatomy of frontal sinus adapted design and an external surgical approach were developed and established. The functionality of the stents was evaluated endoscopically. The stent-tissue blocks were analysed after 90 and 180 days using microcomputed tomography (µ-CT), histology, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS). Functional evaluation revealed an unobstructed stent lumen in all cases. Histological analysis showed moderate mucosal hyperplasia with a mild, nonspecific inflammatory response, and nonosteoconductive effect. Rejection reactions or necrosis did not occur. The volumetric analysis of the stents showed 51% volume loss after 180 days. The EDS analysis did not detect any neodymium (Nd) in the mucosa or bone. The Mg–2 wt % Nd stents are a promising option when treating the narrow passages following paranasal sinus surgery. In particular, its good biocompatibility and good functionality facilitate the re-epithelization of these constricted passages.
AB - Despite innovative surgical techniques and use of current frontal sinus stents from different materials, the problem of treatment failure with consecutive reoperation remains present. The aim of our study is to investigate biocompatibility, degradation kinetics, and functionality of a newly developed fluoride-coated magnesium-based nasal stent. A minipig anatomy of frontal sinus adapted design and an external surgical approach were developed and established. The functionality of the stents was evaluated endoscopically. The stent-tissue blocks were analysed after 90 and 180 days using microcomputed tomography (µ-CT), histology, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS). Functional evaluation revealed an unobstructed stent lumen in all cases. Histological analysis showed moderate mucosal hyperplasia with a mild, nonspecific inflammatory response, and nonosteoconductive effect. Rejection reactions or necrosis did not occur. The volumetric analysis of the stents showed 51% volume loss after 180 days. The EDS analysis did not detect any neodymium (Nd) in the mucosa or bone. The Mg–2 wt % Nd stents are a promising option when treating the narrow passages following paranasal sinus surgery. In particular, its good biocompatibility and good functionality facilitate the re-epithelization of these constricted passages.
KW - biocompatibility
KW - ENT surgery
KW - magnesium
KW - mucosa
KW - nasal stent
UR - http://www.scopus.com/inward/record.url?scp=84945966190&partnerID=8YFLogxK
U2 - 10.1002/jbm.b.33559
DO - 10.1002/jbm.b.33559
M3 - Article
C2 - 26511430
AN - SCOPUS:84945966190
VL - 105
SP - 350
EP - 365
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
SN - 1552-4973
IS - 2
ER -